Use, exposure and omics characterisation of potential hazard in nanomaterials
Nanomaterials offer the potential for positive technological impact in a variety of industries. The major breakthrough is in neurological therapeutic applications as their physical and chemical properties allow them to penetrate the blood-brain barrier (BBB). However, questions concerning its safety...
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| Format: | Article |
| Language: | English |
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ELSEVIER
2023
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| Online Access: | http://eprints.uthm.edu.my/8817/1/J15847_33d051e5d12dd2f5ea8c23aea5b14bc3.pdf |
| _version_ | 1825710645188755456 |
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| author | Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Suzana Misbah, Suzana Misbah Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne |
| author_facet | Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Suzana Misbah, Suzana Misbah Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne |
| author_sort | Nyuk Ling Ma, Nyuk Ling Ma |
| collection | UTHM |
| description | Nanomaterials offer the potential for positive technological impact in a variety of industries. The major breakthrough is in neurological therapeutic applications as their physical and chemical properties allow them to penetrate the blood-brain barrier (BBB). However, questions concerning its safety have arisen as a result of its permeability and the broad application of nanomaterials especially the engineered nanomaterial (ENMs). Due to the large spectrum of ENM properties, pinpointing individual features that caused toxicity is difficult. It is therefore urgent to capitalise on these new developments in ENM safety evaluation. Indeed, novel risk assessment and risk management techniques for humans and the environment across the whole life-cycle of nanomaterial products have emerged in recent years, including systems biology approaches and high-throughput screening platforms. Moreover, the new toxicology
technology should practically reduce the number of animal samples required for testing and allow both in vitro and in vivo cell studies. Unlike traditional cytotoxicity, which limits the analysis effect to a single experiment, hazardous risk assessment by integrated omics technologies using high-throughput technologies provides robustness of systemic functional analysis towards ENM, allowing the discovery of
biomarkers and functional pathways affecting ENM safety application |
| first_indexed | 2024-03-05T22:00:46Z |
| format | Article |
| id | uthm.eprints-8817 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:00:46Z |
| publishDate | 2023 |
| publisher | ELSEVIER |
| record_format | dspace |
| spelling | uthm.eprints-88172023-06-14T00:45:27Z http://eprints.uthm.edu.my/8817/ Use, exposure and omics characterisation of potential hazard in nanomaterials Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Suzana Misbah, Suzana Misbah Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne TA349-359 Mechanics of engineering. Applied mechanics Nanomaterials offer the potential for positive technological impact in a variety of industries. The major breakthrough is in neurological therapeutic applications as their physical and chemical properties allow them to penetrate the blood-brain barrier (BBB). However, questions concerning its safety have arisen as a result of its permeability and the broad application of nanomaterials especially the engineered nanomaterial (ENMs). Due to the large spectrum of ENM properties, pinpointing individual features that caused toxicity is difficult. It is therefore urgent to capitalise on these new developments in ENM safety evaluation. Indeed, novel risk assessment and risk management techniques for humans and the environment across the whole life-cycle of nanomaterial products have emerged in recent years, including systems biology approaches and high-throughput screening platforms. Moreover, the new toxicology technology should practically reduce the number of animal samples required for testing and allow both in vitro and in vivo cell studies. Unlike traditional cytotoxicity, which limits the analysis effect to a single experiment, hazardous risk assessment by integrated omics technologies using high-throughput technologies provides robustness of systemic functional analysis towards ENM, allowing the discovery of biomarkers and functional pathways affecting ENM safety application ELSEVIER 2023 Article PeerReviewed text en http://eprints.uthm.edu.my/8817/1/J15847_33d051e5d12dd2f5ea8c23aea5b14bc3.pdf Nyuk Ling Ma, Nyuk Ling Ma and Nan Zhang, Nan Zhang and Wilson Thau Lym Yong, Wilson Thau Lym Yong and Suzana Misbah, Suzana Misbah and Hashim, Fatimah and Chin Fhong Soon, Chin Fhong Soon and Gim Pao Lim, Gim Pao Lim and Wanxi Peng, Wanxi Peng and Christian Sonne, Christian Sonne (2023) Use, exposure and omics characterisation of potential hazard in nanomaterials. Materials Today Advances, 17. pp. 1-13. https://doi.org/10.1016/j.mtadv.2023.100341 |
| spellingShingle | TA349-359 Mechanics of engineering. Applied mechanics Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Suzana Misbah, Suzana Misbah Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne Use, exposure and omics characterisation of potential hazard in nanomaterials |
| title | Use, exposure and omics characterisation of potential hazard in
nanomaterials |
| title_full | Use, exposure and omics characterisation of potential hazard in
nanomaterials |
| title_fullStr | Use, exposure and omics characterisation of potential hazard in
nanomaterials |
| title_full_unstemmed | Use, exposure and omics characterisation of potential hazard in
nanomaterials |
| title_short | Use, exposure and omics characterisation of potential hazard in
nanomaterials |
| title_sort | use exposure and omics characterisation of potential hazard in nanomaterials |
| topic | TA349-359 Mechanics of engineering. Applied mechanics |
| url | http://eprints.uthm.edu.my/8817/1/J15847_33d051e5d12dd2f5ea8c23aea5b14bc3.pdf |
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