Synthesis and Characterization of Curcumin-Chitosan Loaded Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application
A breakthrough in cosmeceuticals by utilizing insects as major ingredients in cosmetic products is gaining popularity. Therefore, the interest in rare sources of ingredients, for instance, from the Oryctes rhinoceros beetle, can bring huge benefits in terms of turning pests into wealth. In this stud...
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| Format: | Article |
| Language: | English |
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Mdpi
2023
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| Online Access: | http://eprints.uthm.edu.my/9240/1/J16029_d86b896539971924450a113f166b32be.pdf |
| _version_ | 1796869928616198144 |
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| author | Zainol Abidin, Nurul Alyani Kormin, Faridah Zainol Abidin, Nurul Akhma Abu Bakar, Mohd Fadzelly Moujdin, Iqbal Ahmed |
| author_facet | Zainol Abidin, Nurul Alyani Kormin, Faridah Zainol Abidin, Nurul Akhma Abu Bakar, Mohd Fadzelly Moujdin, Iqbal Ahmed |
| author_sort | Zainol Abidin, Nurul Alyani |
| collection | UTHM |
| description | A breakthrough in cosmeceuticals by utilizing insects as major ingredients in cosmetic products is gaining popularity. Therefore, the interest in rare sources of ingredients, for instance, from the Oryctes rhinoceros beetle, can bring huge benefits in terms of turning pests into wealth. In this study, curcumin was chosen as the active ingredient loaded into chitosan-gold nanoparticles (CCG-NP). Curcumin is unstable and has poor absorption, a high rate of metabolism, and high
sensitivity to light. These are all factors that contribute to the low bioavailability of any substance to reach the target cells. Therefore, chitosan extracted from O. rhinoceros could be used as a drug carrier to overcome these limitations. In order to overcome these limitations, CCG-NPs were synthesized and characterized. Chitosan was isolated from O. rhinoceros and CCG-NPs were successfully synthesized at 70 ◦C for 60 min under optimal conditions of a reactant ratio of 2:0.5 (0.5 mM HAuCl4 : 0.1% curcumin). Characterizations of CCG-NP involved FTIR analysis, zeta potential, morphological
properties determination by FE-SEM, particle size analysis, crystallinity study by XRD, and elemental analysis by EDX. The shape of the CCG-NP was round, its size was 128.27 d.nm, and the value of the zeta potential was 20.2 ± 3.81 mV. The IC50 value for cell viability is 58%, indicating a mild toxicity
trait. To conclude, CCG-NP is a stable, spherical, nano-sized, non-toxic, and homogeneous solution. |
| first_indexed | 2024-03-05T22:02:01Z |
| format | Article |
| id | uthm.eprints-9240 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:02:01Z |
| publishDate | 2023 |
| publisher | Mdpi |
| record_format | dspace |
| spelling | uthm.eprints-92402023-07-17T07:41:47Z http://eprints.uthm.edu.my/9240/ Synthesis and Characterization of Curcumin-Chitosan Loaded Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application Zainol Abidin, Nurul Alyani Kormin, Faridah Zainol Abidin, Nurul Akhma Abu Bakar, Mohd Fadzelly Moujdin, Iqbal Ahmed T Technology (General) A breakthrough in cosmeceuticals by utilizing insects as major ingredients in cosmetic products is gaining popularity. Therefore, the interest in rare sources of ingredients, for instance, from the Oryctes rhinoceros beetle, can bring huge benefits in terms of turning pests into wealth. In this study, curcumin was chosen as the active ingredient loaded into chitosan-gold nanoparticles (CCG-NP). Curcumin is unstable and has poor absorption, a high rate of metabolism, and high sensitivity to light. These are all factors that contribute to the low bioavailability of any substance to reach the target cells. Therefore, chitosan extracted from O. rhinoceros could be used as a drug carrier to overcome these limitations. In order to overcome these limitations, CCG-NPs were synthesized and characterized. Chitosan was isolated from O. rhinoceros and CCG-NPs were successfully synthesized at 70 ◦C for 60 min under optimal conditions of a reactant ratio of 2:0.5 (0.5 mM HAuCl4 : 0.1% curcumin). Characterizations of CCG-NP involved FTIR analysis, zeta potential, morphological properties determination by FE-SEM, particle size analysis, crystallinity study by XRD, and elemental analysis by EDX. The shape of the CCG-NP was round, its size was 128.27 d.nm, and the value of the zeta potential was 20.2 ± 3.81 mV. The IC50 value for cell viability is 58%, indicating a mild toxicity trait. To conclude, CCG-NP is a stable, spherical, nano-sized, non-toxic, and homogeneous solution. Mdpi 2023 Article PeerReviewed text en http://eprints.uthm.edu.my/9240/1/J16029_d86b896539971924450a113f166b32be.pdf Zainol Abidin, Nurul Alyani and Kormin, Faridah and Zainol Abidin, Nurul Akhma and Abu Bakar, Mohd Fadzelly and Moujdin, Iqbal Ahmed (2023) Synthesis and Characterization of Curcumin-Chitosan Loaded Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application. Molecules, 28 (1799). pp. 1-12. https://doi.org/10.3390/molecules28041799 |
| spellingShingle | T Technology (General) Zainol Abidin, Nurul Alyani Kormin, Faridah Zainol Abidin, Nurul Akhma Abu Bakar, Mohd Fadzelly Moujdin, Iqbal Ahmed Synthesis and Characterization of Curcumin-Chitosan Loaded Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application |
| title | Synthesis and Characterization of Curcumin-Chitosan Loaded
Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application |
| title_full | Synthesis and Characterization of Curcumin-Chitosan Loaded
Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application |
| title_fullStr | Synthesis and Characterization of Curcumin-Chitosan Loaded
Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application |
| title_full_unstemmed | Synthesis and Characterization of Curcumin-Chitosan Loaded
Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application |
| title_short | Synthesis and Characterization of Curcumin-Chitosan Loaded
Gold Nanoparticles by Oryctes rhinoceros’ Chitin for Cosmeceutical Application |
| title_sort | synthesis and characterization of curcumin chitosan loaded gold nanoparticles by oryctes rhinoceros chitin for cosmeceutical application |
| topic | T Technology (General) |
| url | http://eprints.uthm.edu.my/9240/1/J16029_d86b896539971924450a113f166b32be.pdf |
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