Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy
The aim of this work was to establish and characterize chitosan/graphene oxide-magnesium oxide (CS/GO-MgO) nanocomposite coatings on biodegradable magnesium-zinc-cerium (Mg-Zn-Ce) alloy. In comparison to that of pure CS coatings, all composite coatings encapsulating GO-MgO had better adhesion streng...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2022
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| Online Access: | http://eprints.utm.my/103284/1/AhmadFauziIsmail2022_DualSynergisticEffectsofMgOGOFillers.pdf |
| _version_ | 1796867430867271680 |
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| author | Baghbaderani, Mohammad Zolfaghari Abazari, Somayeh Bakhsheshi-Rad, Hamid Reza Ismail, Ahmad Fauzi Sharif, Safian Najafinezhad, Aliakbar Ramakrishna, Seeram Daroonparvar, Mohammadreza Berto, Filippo |
| author_facet | Baghbaderani, Mohammad Zolfaghari Abazari, Somayeh Bakhsheshi-Rad, Hamid Reza Ismail, Ahmad Fauzi Sharif, Safian Najafinezhad, Aliakbar Ramakrishna, Seeram Daroonparvar, Mohammadreza Berto, Filippo |
| author_sort | Baghbaderani, Mohammad Zolfaghari |
| collection | ePrints |
| description | The aim of this work was to establish and characterize chitosan/graphene oxide-magnesium oxide (CS/GO-MgO) nanocomposite coatings on biodegradable magnesium-zinc-cerium (Mg-Zn-Ce) alloy. In comparison to that of pure CS coatings, all composite coatings encapsulating GO-MgO had better adhesion strength to the Mg-Zn-Ce alloy substrate. The result depicted that the co-encapsulation of GO-MgO into the CS layer leads to diminish of contact angle value and hence escalates the hydrophilic characteristic of coated Mg alloy. The electrochemical test demonstrated that the CS/GO-MgO coatings significantly increased the corrosion resistance because of the synergistic effect of the GO and MgO inside the CS coating. The composite coating escalated cell viability and cell differentiation, according to cytocompatibility tests due to the presence of GO and MgO within the CS. The inclusion of GO-MgO in CS film, on the other hand, accelerates the formation of hydroxyapatite (HA) during 14 days immersion in SBF. Immersion results, including weight loss and hydrogen evolution tests, presented that CS/GO-MgO coating enables a considerably reduced degradation rate of Mg-Zn-Ce alloy when compared to the bare alloy. In terms of antibacterial-inhibition properties, the GO-MgO/CS coatings on Mg substrates showed antibacterial activity against Escherichia coli (E. coli), with a large inhibition area around the specimens, particularly for the coating containing a higher concentration of GO-MgO. Bacterial growth was not inhibited by the bare Mg alloy samples. The CS/GO-MgO composite coating is regarded as a great film to enhance the corrosion resistance, bioactivity, and antibacterial performance of Mg alloy implants. |
| first_indexed | 2024-03-05T21:27:08Z |
| format | Article |
| id | utm.eprints-103284 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T21:27:08Z |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | utm.eprints-1032842023-10-31T01:36:06Z http://eprints.utm.my/103284/ Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy Baghbaderani, Mohammad Zolfaghari Abazari, Somayeh Bakhsheshi-Rad, Hamid Reza Ismail, Ahmad Fauzi Sharif, Safian Najafinezhad, Aliakbar Ramakrishna, Seeram Daroonparvar, Mohammadreza Berto, Filippo TP Chemical technology The aim of this work was to establish and characterize chitosan/graphene oxide-magnesium oxide (CS/GO-MgO) nanocomposite coatings on biodegradable magnesium-zinc-cerium (Mg-Zn-Ce) alloy. In comparison to that of pure CS coatings, all composite coatings encapsulating GO-MgO had better adhesion strength to the Mg-Zn-Ce alloy substrate. The result depicted that the co-encapsulation of GO-MgO into the CS layer leads to diminish of contact angle value and hence escalates the hydrophilic characteristic of coated Mg alloy. The electrochemical test demonstrated that the CS/GO-MgO coatings significantly increased the corrosion resistance because of the synergistic effect of the GO and MgO inside the CS coating. The composite coating escalated cell viability and cell differentiation, according to cytocompatibility tests due to the presence of GO and MgO within the CS. The inclusion of GO-MgO in CS film, on the other hand, accelerates the formation of hydroxyapatite (HA) during 14 days immersion in SBF. Immersion results, including weight loss and hydrogen evolution tests, presented that CS/GO-MgO coating enables a considerably reduced degradation rate of Mg-Zn-Ce alloy when compared to the bare alloy. In terms of antibacterial-inhibition properties, the GO-MgO/CS coatings on Mg substrates showed antibacterial activity against Escherichia coli (E. coli), with a large inhibition area around the specimens, particularly for the coating containing a higher concentration of GO-MgO. Bacterial growth was not inhibited by the bare Mg alloy samples. The CS/GO-MgO composite coating is regarded as a great film to enhance the corrosion resistance, bioactivity, and antibacterial performance of Mg alloy implants. MDPI 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/103284/1/AhmadFauziIsmail2022_DualSynergisticEffectsofMgOGOFillers.pdf Baghbaderani, Mohammad Zolfaghari and Abazari, Somayeh and Bakhsheshi-Rad, Hamid Reza and Ismail, Ahmad Fauzi and Sharif, Safian and Najafinezhad, Aliakbar and Ramakrishna, Seeram and Daroonparvar, Mohammadreza and Berto, Filippo (2022) Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy. Coatings, 12 (1). pp. 1-17. ISSN 2079-6412 http://dx.doi.org/10.3390/coatings12010063 DOI : 10.3390/coatings12010063 |
| spellingShingle | TP Chemical technology Baghbaderani, Mohammad Zolfaghari Abazari, Somayeh Bakhsheshi-Rad, Hamid Reza Ismail, Ahmad Fauzi Sharif, Safian Najafinezhad, Aliakbar Ramakrishna, Seeram Daroonparvar, Mohammadreza Berto, Filippo Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy |
| title | Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy |
| title_full | Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy |
| title_fullStr | Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy |
| title_full_unstemmed | Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy |
| title_short | Dual synergistic effects of MgO-GO Fillers on degradation behavior, biocompatibility and antibacterial activities of chitosan coated Mg alloy |
| title_sort | dual synergistic effects of mgo go fillers on degradation behavior biocompatibility and antibacterial activities of chitosan coated mg alloy |
| topic | TP Chemical technology |
| url | http://eprints.utm.my/103284/1/AhmadFauziIsmail2022_DualSynergisticEffectsofMgOGOFillers.pdf |
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