Vaccines for Orthopoxviruses: a review
Human and animal infections with Orthopoxvirus have become more prevalent in recent years. Although smallpox has been eradicated, vaccinations continue to play a role in controlling the spread of Orthopoxvirus diseases. First generation vaccines were successfully commercialized, and they were widely...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia
2023
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| Online Access: | http://eprints.utm.my/105429/1/DanielJoeDailin2023_VaccinesforOrthopoxvirusesaReview.pdf |
| _version_ | 1811132132251140096 |
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| author | Che Marzuki, Che Nur Irfan Firdaus Mat Zaid, Azra Juliana Azman, Farah Wahida Joepri, Isnimyati Dailin, Daniel Joe El Enshasy, Hesham Ali Teo, Siew Hway Tong, Woei Yenn |
| author_facet | Che Marzuki, Che Nur Irfan Firdaus Mat Zaid, Azra Juliana Azman, Farah Wahida Joepri, Isnimyati Dailin, Daniel Joe El Enshasy, Hesham Ali Teo, Siew Hway Tong, Woei Yenn |
| author_sort | Che Marzuki, Che Nur Irfan Firdaus |
| collection | ePrints |
| description | Human and animal infections with Orthopoxvirus have become more prevalent in recent years. Although smallpox has been eradicated, vaccinations continue to play a role in controlling the spread of Orthopoxvirus diseases. First generation vaccines were successfully commercialized, and they were widely used previously. Besides, several second-generation vaccines that emphasize sterile cell culture techniques for vaccine production have been developed. Some of the third-generation vaccines also successfully trigger immune responses in the host, and they are being researched as safer substitutes for smallpox vaccines. Extensive work is still being done on the creation of fourth-generation smallpox vaccines, which include the creation of DNA subunit vaccines. Clinical studies must be conducted to evaluate the efficacies of these vaccines. Vaccine was effective in preventing smallpox infection. To achieve the Sustainable Development Goals of the United Nations, a new paradigm for vaccination research and product development must be established. |
| first_indexed | 2024-09-23T23:57:23Z |
| format | Article |
| id | utm.eprints-105429 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-09-23T23:57:23Z |
| publishDate | 2023 |
| publisher | Universiti Putra Malaysia |
| record_format | dspace |
| spelling | utm.eprints-1054292024-04-28T09:19:43Z http://eprints.utm.my/105429/ Vaccines for Orthopoxviruses: a review Che Marzuki, Che Nur Irfan Firdaus Mat Zaid, Azra Juliana Azman, Farah Wahida Joepri, Isnimyati Dailin, Daniel Joe El Enshasy, Hesham Ali Teo, Siew Hway Tong, Woei Yenn Q Science (General) R Medicine (General) Human and animal infections with Orthopoxvirus have become more prevalent in recent years. Although smallpox has been eradicated, vaccinations continue to play a role in controlling the spread of Orthopoxvirus diseases. First generation vaccines were successfully commercialized, and they were widely used previously. Besides, several second-generation vaccines that emphasize sterile cell culture techniques for vaccine production have been developed. Some of the third-generation vaccines also successfully trigger immune responses in the host, and they are being researched as safer substitutes for smallpox vaccines. Extensive work is still being done on the creation of fourth-generation smallpox vaccines, which include the creation of DNA subunit vaccines. Clinical studies must be conducted to evaluate the efficacies of these vaccines. Vaccine was effective in preventing smallpox infection. To achieve the Sustainable Development Goals of the United Nations, a new paradigm for vaccination research and product development must be established. Universiti Putra Malaysia 2023-08 Article PeerReviewed application/pdf en http://eprints.utm.my/105429/1/DanielJoeDailin2023_VaccinesforOrthopoxvirusesaReview.pdf Che Marzuki, Che Nur Irfan Firdaus and Mat Zaid, Azra Juliana and Azman, Farah Wahida and Joepri, Isnimyati and Dailin, Daniel Joe and El Enshasy, Hesham Ali and Teo, Siew Hway and Tong, Woei Yenn (2023) Vaccines for Orthopoxviruses: a review. Malaysian Journal of Medicine and Health Sciences, 19 (SUPP9). pp. 308-312. ISSN 1675-8544 http://dx.doi.org/10.47836/MJMHS.19.S9.41 DOI:10.47836/MJMHS.19.S9.41 |
| spellingShingle | Q Science (General) R Medicine (General) Che Marzuki, Che Nur Irfan Firdaus Mat Zaid, Azra Juliana Azman, Farah Wahida Joepri, Isnimyati Dailin, Daniel Joe El Enshasy, Hesham Ali Teo, Siew Hway Tong, Woei Yenn Vaccines for Orthopoxviruses: a review |
| title | Vaccines for Orthopoxviruses: a review |
| title_full | Vaccines for Orthopoxviruses: a review |
| title_fullStr | Vaccines for Orthopoxviruses: a review |
| title_full_unstemmed | Vaccines for Orthopoxviruses: a review |
| title_short | Vaccines for Orthopoxviruses: a review |
| title_sort | vaccines for orthopoxviruses a review |
| topic | Q Science (General) R Medicine (General) |
| url | http://eprints.utm.my/105429/1/DanielJoeDailin2023_VaccinesforOrthopoxvirusesaReview.pdf |
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