Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers
Hyperglycemia, a distinguishing feature of diabetes mellitus that might cause a diabetic foot ulcer (DFU), is an endocrine disorder that affects an extremely high percentage of people. Having a comprehensive understanding of the molecular mechanisms underlying the pathophysiology of diabetic wound h...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
John Wiley and Sons Ltd
2023
|
| Subjects: |
| _version_ | 1811132202734321664 |
|---|---|
| author | Hosseinzadeh, Ahmad Zamani, Ali Johari, Hamed Ghoddusi Vaez, Ahmad Golchin, Ali Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Mohammad Amani, Ali Chelliapan, Shreeshivadasan Kamyab, Hesam Anbardar, Mohammad Hossein Jangjou, Ali |
| author_facet | Hosseinzadeh, Ahmad Zamani, Ali Johari, Hamed Ghoddusi Vaez, Ahmad Golchin, Ali Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Mohammad Amani, Ali Chelliapan, Shreeshivadasan Kamyab, Hesam Anbardar, Mohammad Hossein Jangjou, Ali |
| author_sort | Hosseinzadeh, Ahmad |
| collection | ePrints |
| description | Hyperglycemia, a distinguishing feature of diabetes mellitus that might cause a diabetic foot ulcer (DFU), is an endocrine disorder that affects an extremely high percentage of people. Having a comprehensive understanding of the molecular mechanisms underlying the pathophysiology of diabetic wound healing can help researchers and developers design effective therapeutic strategies to treat the wound healing process in diabetes patients. Using nanoscaffolds and nanotherapeutics with dimensions ranging from 1 to 100 nm represents a state-of-the-art and viable therapeutic strategy for accelerating the wound healing process in diabetic patients, particularly those with DFU. Nanoparticles can interact with biological constituents and infiltrate wound sites owing to their reduced diameter and enhanced surface area. Furthermore, it is noteworthy that they promote the processes of vascularization, cellular proliferation, cell signaling, cell-to-cell interactions, and the formation of biomolecules that are essential for effective wound healing. Nanomaterials possess the ability to effectively transport and deliver various pharmacological agents, such as nucleic acids, growth factors, antioxidants, and antibiotics, to specific tissues, where they can be continuously released and affect the wound healing process in DFU. The present article elucidates the ongoing endeavors in the field of nanoparticle-mediated therapies for the management of DFU. |
| first_indexed | 2024-09-23T23:59:37Z |
| format | Article |
| id | utm.eprints-105785 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-09-23T23:59:37Z |
| publishDate | 2023 |
| publisher | John Wiley and Sons Ltd |
| record_format | dspace |
| spelling | utm.eprints-1057852024-05-20T06:31:52Z http://eprints.utm.my/105785/ Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers Hosseinzadeh, Ahmad Zamani, Ali Johari, Hamed Ghoddusi Vaez, Ahmad Golchin, Ali Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Mohammad Amani, Ali Chelliapan, Shreeshivadasan Kamyab, Hesam Anbardar, Mohammad Hossein Jangjou, Ali T Technology (General) Hyperglycemia, a distinguishing feature of diabetes mellitus that might cause a diabetic foot ulcer (DFU), is an endocrine disorder that affects an extremely high percentage of people. Having a comprehensive understanding of the molecular mechanisms underlying the pathophysiology of diabetic wound healing can help researchers and developers design effective therapeutic strategies to treat the wound healing process in diabetes patients. Using nanoscaffolds and nanotherapeutics with dimensions ranging from 1 to 100 nm represents a state-of-the-art and viable therapeutic strategy for accelerating the wound healing process in diabetic patients, particularly those with DFU. Nanoparticles can interact with biological constituents and infiltrate wound sites owing to their reduced diameter and enhanced surface area. Furthermore, it is noteworthy that they promote the processes of vascularization, cellular proliferation, cell signaling, cell-to-cell interactions, and the formation of biomolecules that are essential for effective wound healing. Nanomaterials possess the ability to effectively transport and deliver various pharmacological agents, such as nucleic acids, growth factors, antioxidants, and antibiotics, to specific tissues, where they can be continuously released and affect the wound healing process in DFU. The present article elucidates the ongoing endeavors in the field of nanoparticle-mediated therapies for the management of DFU. John Wiley and Sons Ltd 2023 Article PeerReviewed Hosseinzadeh, Ahmad and Zamani, Ali and Johari, Hamed Ghoddusi and Vaez, Ahmad and Golchin, Ali and Tayebi, Lobat and Vafa, Ehsan and Abbasi, Milad and Mohammad Amani, Ali and Chelliapan, Shreeshivadasan and Kamyab, Hesam and Anbardar, Mohammad Hossein and Jangjou, Ali (2023) Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers. Cell Biochemistry and Function, 41 (5). pp. 517-541. ISSN 0263-6484 http://dx.doi.org/10.1002/cbf.3816 DOI : 10.1002/cbf.3816 |
| spellingShingle | T Technology (General) Hosseinzadeh, Ahmad Zamani, Ali Johari, Hamed Ghoddusi Vaez, Ahmad Golchin, Ali Tayebi, Lobat Vafa, Ehsan Abbasi, Milad Mohammad Amani, Ali Chelliapan, Shreeshivadasan Kamyab, Hesam Anbardar, Mohammad Hossein Jangjou, Ali Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers |
| title | Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers |
| title_full | Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers |
| title_fullStr | Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers |
| title_full_unstemmed | Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers |
| title_short | Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle-based therapeutic strategies for the management and treatment of diabetic foot ulcers |
| title_sort | moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine effective nanoparticle based therapeutic strategies for the management and treatment of diabetic foot ulcers |
| topic | T Technology (General) |
| work_keys_str_mv | AT hosseinzadehahmad movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT zamaniali movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT joharihamedghoddusi movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT vaezahmad movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT golchinali movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT tayebilobat movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT vafaehsan movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT abbasimilad movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT mohammadamaniali movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT chelliapanshreeshivadasan movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT kamyabhesam movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT anbardarmohammadhossein movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers AT jangjouali movingbeyondnanotechnologytouncoveraglimmerofhopeindiabetesmedicineeffectivenanoparticlebasedtherapeuticstrategiesforthemanagementandtreatmentofdiabeticfootulcers |