The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats
In utero bisphenol A (BPA) exposure has been reported to increase the risk of cardiovascular disease (CVD) in adult life. Thus, this study aimed to investigate the impact of in utero BPA exposure on proteins expression related to cardiac function in heart of rat foetuses (Rattus norvegicus). In here...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit UKM
2023
|
| Subjects: | |
| Online Access: | http://eprints.utm.my/106727/1/MohdHafizDzarfan2023_TheImpactofBisphenolAExposureduringPregnancy.pdf |
| _version_ | 1811132400146579456 |
|---|---|
| author | Rasdi, Zatilfarihiah Kamaludin, Roziana Sheikh Abdul Kadir, Siti Hamimah Mohd. Efendy Goon, Mohd. Danial Khan, Jesmine Ab. Rahim, Sharaniza Othman, Mohd. Hafiz Dzarfan |
| author_facet | Rasdi, Zatilfarihiah Kamaludin, Roziana Sheikh Abdul Kadir, Siti Hamimah Mohd. Efendy Goon, Mohd. Danial Khan, Jesmine Ab. Rahim, Sharaniza Othman, Mohd. Hafiz Dzarfan |
| author_sort | Rasdi, Zatilfarihiah |
| collection | ePrints |
| description | In utero bisphenol A (BPA) exposure has been reported to increase the risk of cardiovascular disease (CVD) in adult life. Thus, this study aimed to investigate the impact of in utero BPA exposure on proteins expression related to cardiac function in heart of rat foetuses (Rattus norvegicus). In here, pregnant rats were divided into tween-80 (vehicle control), 0.05 mg/mL and 0.2 mg/mL BPA via drinking water for 19 days: from pregnancy day 2 till 21. Caesarean section was conducted on pregnancy day 21 to collect plasma and heart of both mother and foetuses. BPA-exposed pregnant rats showed significant increase in blood pressure (BP) and reduction in glycogen content (p<0.05) in comparison to control pregnant rats. Remarkably, reduced expression of cardiac troponin I (cTnI) and redistribution of alpha fetoprotein (AFP) expression were in foetus of BPA-exposed mother in comparison with foetus of control mother. Hypoxia induced factor-1 alpha (HIF-1α) expression was elevated in BPA-exposed foetal heart compared to the control. The findings in here suggest the risk of in utero BPA exposure on both foetus and mother, which may increase the risk of CVD in later life by altering the expression of protein crucial for heart development and function. |
| first_indexed | 2024-09-24T00:03:27Z |
| format | Article |
| id | utm.eprints-106727 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-09-24T00:03:27Z |
| publishDate | 2023 |
| publisher | Penerbit UKM |
| record_format | dspace |
| spelling | utm.eprints-1067272024-07-28T06:08:43Z http://eprints.utm.my/106727/ The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats Rasdi, Zatilfarihiah Kamaludin, Roziana Sheikh Abdul Kadir, Siti Hamimah Mohd. Efendy Goon, Mohd. Danial Khan, Jesmine Ab. Rahim, Sharaniza Othman, Mohd. Hafiz Dzarfan Q Science (General) RA Public aspects of medicine In utero bisphenol A (BPA) exposure has been reported to increase the risk of cardiovascular disease (CVD) in adult life. Thus, this study aimed to investigate the impact of in utero BPA exposure on proteins expression related to cardiac function in heart of rat foetuses (Rattus norvegicus). In here, pregnant rats were divided into tween-80 (vehicle control), 0.05 mg/mL and 0.2 mg/mL BPA via drinking water for 19 days: from pregnancy day 2 till 21. Caesarean section was conducted on pregnancy day 21 to collect plasma and heart of both mother and foetuses. BPA-exposed pregnant rats showed significant increase in blood pressure (BP) and reduction in glycogen content (p<0.05) in comparison to control pregnant rats. Remarkably, reduced expression of cardiac troponin I (cTnI) and redistribution of alpha fetoprotein (AFP) expression were in foetus of BPA-exposed mother in comparison with foetus of control mother. Hypoxia induced factor-1 alpha (HIF-1α) expression was elevated in BPA-exposed foetal heart compared to the control. The findings in here suggest the risk of in utero BPA exposure on both foetus and mother, which may increase the risk of CVD in later life by altering the expression of protein crucial for heart development and function. Penerbit UKM 2023-05 Article PeerReviewed application/pdf en http://eprints.utm.my/106727/1/MohdHafizDzarfan2023_TheImpactofBisphenolAExposureduringPregnancy.pdf Rasdi, Zatilfarihiah and Kamaludin, Roziana and Sheikh Abdul Kadir, Siti Hamimah and Mohd. Efendy Goon, Mohd. Danial and Khan, Jesmine and Ab. Rahim, Sharaniza and Othman, Mohd. Hafiz Dzarfan (2023) The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats. Sains Malaysiana, 52 (5). pp. 1497-1511. ISSN 0126-6039 http://dx.doi.org/10.17576/jsm-2023-5205-13 DOI:10.17576/jsm-2023-5205-13 |
| spellingShingle | Q Science (General) RA Public aspects of medicine Rasdi, Zatilfarihiah Kamaludin, Roziana Sheikh Abdul Kadir, Siti Hamimah Mohd. Efendy Goon, Mohd. Danial Khan, Jesmine Ab. Rahim, Sharaniza Othman, Mohd. Hafiz Dzarfan The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats |
| title | The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats |
| title_full | The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats |
| title_fullStr | The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats |
| title_full_unstemmed | The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats |
| title_short | The impact of bisphenol A exposure during pregnancy on the heart of mother and fetal rats |
| title_sort | impact of bisphenol a exposure during pregnancy on the heart of mother and fetal rats |
| topic | Q Science (General) RA Public aspects of medicine |
| url | http://eprints.utm.my/106727/1/MohdHafizDzarfan2023_TheImpactofBisphenolAExposureduringPregnancy.pdf |
| work_keys_str_mv | AT rasdizatilfarihiah theimpactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT kamaludinroziana theimpactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT sheikhabdulkadirsitihamimah theimpactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT mohdefendygoonmohddanial theimpactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT khanjesmine theimpactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT abrahimsharaniza theimpactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT othmanmohdhafizdzarfan theimpactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT rasdizatilfarihiah impactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT kamaludinroziana impactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT sheikhabdulkadirsitihamimah impactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT mohdefendygoonmohddanial impactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT khanjesmine impactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT abrahimsharaniza impactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats AT othmanmohdhafizdzarfan impactofbisphenolaexposureduringpregnancyontheheartofmotherandfetalrats |