Evaluation of the insulinotrophic activity of Malaysian traditional plants extract
In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic ß-cell lines, BRIN-BD11 cells. In 30 min acute static incubation test, all 14 plants showed varying degree of responsiveness in insulin release with Labisa pumil...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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ANSInet
2008
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| Online Access: | http://eprints.utm.my/12560/1/muhajirhamid2008_Evaluation%20of%20the%20insulinotrophic%20activity.pdf |
| _version_ | 1796855100039233536 |
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| author | Hamid, Muhajir Mohd. Bohari, Siti Pauliena Bastami, Mohd. Saufi Ali, Abdul Manaf Mustapha, Nik Musa’ adah Shari, Khozirah |
| author_facet | Hamid, Muhajir Mohd. Bohari, Siti Pauliena Bastami, Mohd. Saufi Ali, Abdul Manaf Mustapha, Nik Musa’ adah Shari, Khozirah |
| author_sort | Hamid, Muhajir |
| collection | ePrints |
| description | In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic ß-cell lines, BRIN-BD11 cells. In 30 min acute static incubation test, all 14 plants showed varying degree of responsiveness in insulin release with Labisa pumila, Morinda citrifolia, Momordica charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cytotoxic activities. These results show a promising avenue for development of novel insulin secretagogues. |
| first_indexed | 2024-03-05T18:23:40Z |
| format | Article |
| id | utm.eprints-12560 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T18:23:40Z |
| publishDate | 2008 |
| publisher | ANSInet |
| record_format | dspace |
| spelling | utm.eprints-125602017-10-25T04:24:56Z http://eprints.utm.my/12560/ Evaluation of the insulinotrophic activity of Malaysian traditional plants extract Hamid, Muhajir Mohd. Bohari, Siti Pauliena Bastami, Mohd. Saufi Ali, Abdul Manaf Mustapha, Nik Musa’ adah Shari, Khozirah Q Science (General) In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic ß-cell lines, BRIN-BD11 cells. In 30 min acute static incubation test, all 14 plants showed varying degree of responsiveness in insulin release with Labisa pumila, Morinda citrifolia, Momordica charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cytotoxic activities. These results show a promising avenue for development of novel insulin secretagogues. ANSInet 2008-01-01 Article PeerReviewed application/pdf en http://eprints.utm.my/12560/1/muhajirhamid2008_Evaluation%20of%20the%20insulinotrophic%20activity.pdf Hamid, Muhajir and Mohd. Bohari, Siti Pauliena and Bastami, Mohd. Saufi and Ali, Abdul Manaf and Mustapha, Nik Musa’ adah and Shari, Khozirah (2008) Evaluation of the insulinotrophic activity of Malaysian traditional plants extract. Journal of Biological Sciences, 8 (1). 201 -204. ISSN 1727-3048 http://dx.doi.org/10.3923/jbs.2008.201.204 doi:10.3923/jbs.2008.201.204 |
| spellingShingle | Q Science (General) Hamid, Muhajir Mohd. Bohari, Siti Pauliena Bastami, Mohd. Saufi Ali, Abdul Manaf Mustapha, Nik Musa’ adah Shari, Khozirah Evaluation of the insulinotrophic activity of Malaysian traditional plants extract |
| title | Evaluation of the insulinotrophic activity of Malaysian traditional plants extract |
| title_full | Evaluation of the insulinotrophic activity of Malaysian traditional plants extract |
| title_fullStr | Evaluation of the insulinotrophic activity of Malaysian traditional plants extract |
| title_full_unstemmed | Evaluation of the insulinotrophic activity of Malaysian traditional plants extract |
| title_short | Evaluation of the insulinotrophic activity of Malaysian traditional plants extract |
| title_sort | evaluation of the insulinotrophic activity of malaysian traditional plants extract |
| topic | Q Science (General) |
| url | http://eprints.utm.my/12560/1/muhajirhamid2008_Evaluation%20of%20the%20insulinotrophic%20activity.pdf |
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