Anti-inflammatory activity of extracts and compounds from Vitex negundo
The anti inflammatory activity of the leaf extract of Vitex negundo was investigated on topical administration using the TPA. (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. The crude methanolic extract of V. negundo showed moderate inhibition (74%) at a dose of 2 mg per ear. Th...
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| Format: | Article |
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Forest Research Institute Malaysia
2005
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| _version_ | 1796855133532848128 |
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| author | Mat Ali, Rasadah Ahmad, Farediah Wong, C. L. Ong, B. K. |
| author_facet | Mat Ali, Rasadah Ahmad, Farediah Wong, C. L. Ong, B. K. |
| author_sort | Mat Ali, Rasadah |
| collection | ePrints |
| description | The anti inflammatory activity of the leaf extract of Vitex negundo was investigated on topical administration using the TPA. (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. The crude methanolic extract of V. negundo showed moderate inhibition (74%) at a dose of 2 mg per ear. The methanol extract was then subjected to liquid-liquid fractionation with petroleum ether, chloroform, ethyl-acetate and ethanol. Bioassay-guided chromatographic fractionation of these fractions led to the isolation of 3,4-dihydroxybenzoic acid as the bioactive principle responsible for the anti-inflammatory activity. The structures of the pure compounds were elucidated using various spectroscopic techniques. |
| first_indexed | 2024-03-05T18:24:10Z |
| format | Article |
| id | utm.eprints-12758 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T18:24:10Z |
| publishDate | 2005 |
| publisher | Forest Research Institute Malaysia |
| record_format | dspace |
| spelling | utm.eprints-127582017-10-25T05:59:45Z http://eprints.utm.my/12758/ Anti-inflammatory activity of extracts and compounds from Vitex negundo Mat Ali, Rasadah Ahmad, Farediah Wong, C. L. Ong, B. K. Q Science (General) QD Chemistry The anti inflammatory activity of the leaf extract of Vitex negundo was investigated on topical administration using the TPA. (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. The crude methanolic extract of V. negundo showed moderate inhibition (74%) at a dose of 2 mg per ear. The methanol extract was then subjected to liquid-liquid fractionation with petroleum ether, chloroform, ethyl-acetate and ethanol. Bioassay-guided chromatographic fractionation of these fractions led to the isolation of 3,4-dihydroxybenzoic acid as the bioactive principle responsible for the anti-inflammatory activity. The structures of the pure compounds were elucidated using various spectroscopic techniques. Forest Research Institute Malaysia 2005 Article PeerReviewed Mat Ali, Rasadah and Ahmad, Farediah and Wong, C. L. and Ong, B. K. (2005) Anti-inflammatory activity of extracts and compounds from Vitex negundo. Journal of Tropical Forest Science, 17 . pp. 481-487. ISSN 01281283 |
| spellingShingle | Q Science (General) QD Chemistry Mat Ali, Rasadah Ahmad, Farediah Wong, C. L. Ong, B. K. Anti-inflammatory activity of extracts and compounds from Vitex negundo |
| title | Anti-inflammatory activity of extracts and compounds from Vitex negundo |
| title_full | Anti-inflammatory activity of extracts and compounds from Vitex negundo |
| title_fullStr | Anti-inflammatory activity of extracts and compounds from Vitex negundo |
| title_full_unstemmed | Anti-inflammatory activity of extracts and compounds from Vitex negundo |
| title_short | Anti-inflammatory activity of extracts and compounds from Vitex negundo |
| title_sort | anti inflammatory activity of extracts and compounds from vitex negundo |
| topic | Q Science (General) QD Chemistry |
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