Penicillin G solubilisation into AOT reverse micelles
Extraction of penicillin G from an aqueous phase into an organic phase containing ACT reverse micelles has been investigated. The extraction is influenced by the initial penicillin G concentration, the salt type and concentration in the aqueous phase, pH, and surfactant concentration. The results sh...
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| Format: | Article |
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Elsevier BV
2009
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| _version_ | 1796855210967040000 |
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| author | Mohd. Setapar, S. H. Wakeman, R. J. Tarleton, E. S. |
| author_facet | Mohd. Setapar, S. H. Wakeman, R. J. Tarleton, E. S. |
| author_sort | Mohd. Setapar, S. H. |
| collection | ePrints |
| description | Extraction of penicillin G from an aqueous phase into an organic phase containing ACT reverse micelles has been investigated. The extraction is influenced by the initial penicillin G concentration, the salt type and concentration in the aqueous phase, pH, and surfactant concentration. The results show that penicillin is an interfacially active compound that interacts with ACT, with the interfacial association being dependent on both pH and surfactant concentration. When the concentration ratio [P](aq)/[S] is high precipitation of the penicillin occurs. The distribution coefficient favours transfer of the penicillin into the reverse micelles at moderate ACT concentrations. The distribution coefficient at infinite dilution, K(infinity), is shown to be a function of both pH and surfactant concentration; similar trends in the value of K(infinity) were observed at different pH values; K(infinity) decreases as the surfactant concentration is increased. Reverse micelle formation affects the volume of water transferred into the organic phase; from measurements of the water transferred, the size of the reverse micelles was estimated to be about 3 nm and the number of ACT molecules per reverse micelle about 360. (C) 2008 The Institution of Chemical Engineers. |
| first_indexed | 2024-03-05T18:25:19Z |
| format | Article |
| id | utm.eprints-13216 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T18:25:19Z |
| publishDate | 2009 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | utm.eprints-132162017-10-25T06:58:47Z http://eprints.utm.my/13216/ Penicillin G solubilisation into AOT reverse micelles Mohd. Setapar, S. H. Wakeman, R. J. Tarleton, E. S. TP Chemical technology Extraction of penicillin G from an aqueous phase into an organic phase containing ACT reverse micelles has been investigated. The extraction is influenced by the initial penicillin G concentration, the salt type and concentration in the aqueous phase, pH, and surfactant concentration. The results show that penicillin is an interfacially active compound that interacts with ACT, with the interfacial association being dependent on both pH and surfactant concentration. When the concentration ratio [P](aq)/[S] is high precipitation of the penicillin occurs. The distribution coefficient favours transfer of the penicillin into the reverse micelles at moderate ACT concentrations. The distribution coefficient at infinite dilution, K(infinity), is shown to be a function of both pH and surfactant concentration; similar trends in the value of K(infinity) were observed at different pH values; K(infinity) decreases as the surfactant concentration is increased. Reverse micelle formation affects the volume of water transferred into the organic phase; from measurements of the water transferred, the size of the reverse micelles was estimated to be about 3 nm and the number of ACT molecules per reverse micelle about 360. (C) 2008 The Institution of Chemical Engineers. Elsevier BV 2009 Article PeerReviewed Mohd. Setapar, S. H. and Wakeman, R. J. and Tarleton, E. S. (2009) Penicillin G solubilisation into AOT reverse micelles. Chemical Engineering Research and Design, 87 (6). pp. 833-842. ISSN 02638762 http://dx.doi.org/10.1016/j.cherd.2008.11.001 doi:10.1016/j.cherd.2008.11.001 |
| spellingShingle | TP Chemical technology Mohd. Setapar, S. H. Wakeman, R. J. Tarleton, E. S. Penicillin G solubilisation into AOT reverse micelles |
| title | Penicillin G solubilisation into AOT reverse micelles |
| title_full | Penicillin G solubilisation into AOT reverse micelles |
| title_fullStr | Penicillin G solubilisation into AOT reverse micelles |
| title_full_unstemmed | Penicillin G solubilisation into AOT reverse micelles |
| title_short | Penicillin G solubilisation into AOT reverse micelles |
| title_sort | penicillin g solubilisation into aot reverse micelles |
| topic | TP Chemical technology |
| work_keys_str_mv | AT mohdsetaparsh penicillingsolubilisationintoaotreversemicelles AT wakemanrj penicillingsolubilisationintoaotreversemicelles AT tarletones penicillingsolubilisationintoaotreversemicelles |