Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.)
Phytochemical investigation of piper sarmentosum roxb., yielded four compunds; three amides, identified as 3-(3'.4'5'-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4'-methoxyphenylpropanoyl) pyrrole, N-(3-phenylpropanoyl) pyrrole and a sterol namely B-sitostrel. 3-(4'-Methoxyph...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2011
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| Online Access: | http://eprints.utm.my/28784/2/413 |
| _version_ | 1796856439685251072 |
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| author | Atiax, E. Ahmad, Farediah Mohd. Sirat, Hasnah Arbain, D. |
| author_facet | Atiax, E. Ahmad, Farediah Mohd. Sirat, Hasnah Arbain, D. |
| author_sort | Atiax, E. |
| collection | ePrints |
| description | Phytochemical investigation of piper sarmentosum roxb., yielded four compunds; three amides, identified as 3-(3'.4'5'-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4'-methoxyphenylpropanoyl) pyrrole, N-(3-phenylpropanoyl) pyrrole and a sterol namely B-sitostrel. 3-(4'-Methoxyphenylpropanoyl) pyrrole was found for the first time in this piper species. All chemical constituents were tested foe their antibacterial activity using disk diffusion method and cytotoxicity screening using sul-forhodamine B (SRB) assay. All of the compounds were found only active towards gram-positive bacteria except 3-(4'-methoxyphenylpropanoyl) pyrrole with no activity against both gram-positive and gram-negative bacteria. Meanwhile, the cytotoxicity screening using SRB assay indicated that none of these compounds was active as an anticancer agent. |
| first_indexed | 2024-03-05T18:42:59Z |
| format | Article |
| id | utm.eprints-28784 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T18:42:59Z |
| publishDate | 2011 |
| publisher | Tehran University of Medical Sciences |
| record_format | dspace |
| spelling | utm.eprints-287842017-10-13T13:02:41Z http://eprints.utm.my/28784/ Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.) Atiax, E. Ahmad, Farediah Mohd. Sirat, Hasnah Arbain, D. Q Science Phytochemical investigation of piper sarmentosum roxb., yielded four compunds; three amides, identified as 3-(3'.4'5'-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4'-methoxyphenylpropanoyl) pyrrole, N-(3-phenylpropanoyl) pyrrole and a sterol namely B-sitostrel. 3-(4'-Methoxyphenylpropanoyl) pyrrole was found for the first time in this piper species. All chemical constituents were tested foe their antibacterial activity using disk diffusion method and cytotoxicity screening using sul-forhodamine B (SRB) assay. All of the compounds were found only active towards gram-positive bacteria except 3-(4'-methoxyphenylpropanoyl) pyrrole with no activity against both gram-positive and gram-negative bacteria. Meanwhile, the cytotoxicity screening using SRB assay indicated that none of these compounds was active as an anticancer agent. Tehran University of Medical Sciences 2011-01 Article PeerReviewed text/html en http://eprints.utm.my/28784/2/413 Atiax, E. and Ahmad, Farediah and Mohd. Sirat, Hasnah and Arbain, D. (2011) Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.). Iranian Journal of Pharmacology and Therapeutics, 10 (1). pp. 1-5. ISSN 1735-2657 http://www.sid.ir/en/VEWSSID/J_pdf/101020110101.pdf |
| spellingShingle | Q Science Atiax, E. Ahmad, Farediah Mohd. Sirat, Hasnah Arbain, D. Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.) |
| title | Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.) |
| title_full | Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.) |
| title_fullStr | Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.) |
| title_full_unstemmed | Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.) |
| title_short | Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.) |
| title_sort | antibacterial activity and cytotoxicity screening of sumatran kaduk piper sarmentosum roxb |
| topic | Q Science |
| url | http://eprints.utm.my/28784/2/413 |
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