Microdosimetry modeling technique for spherical cell
Electroporation is a process of the bio-physical effect on cells exposed to an external electrical field is gaining applications in medical treatments, especially to create pores through a cell membrane and allow uptake of DNA into a cell. The efficacy of this treatment depends on the magnitude and...
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| Format: | Book Section |
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Springer Berlin Heidelberg
2011
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| _version_ | 1796856539921776640 |
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| author | Nazib Adon, M. Noh Dalimin, M. Mohd. Kassim, Norazan Abdul Jamil, M. M. |
| author_facet | Nazib Adon, M. Noh Dalimin, M. Mohd. Kassim, Norazan Abdul Jamil, M. M. |
| author_sort | Nazib Adon, M. |
| collection | ePrints |
| description | Electroporation is a process of the bio-physical effect on cells exposed to an external electrical field is gaining applications in medical treatments, especially to create pores through a cell membrane and allow uptake of DNA into a cell. The efficacy of this treatment depends on the magnitude and the distribution of electric field applied, in addition to the physiological parameters, such as the conductivities and relative permittivities of the cell membranes and cytoplasm. In addition, physical parameters, such as the thickness and size of the cell also influence the efficiency of the electroporation technique. In this research, the electric field distributions of spherical cells were studied using Finite Integration Techniques (FIT), to explicate the difference in responses of the analytical and numerical cells for a given input voltage. For this purpose, quasistatic approach based on CST EM STUDIO® software was used. A comparison of the induced transmembrane potential of the analytical against numerical technique shows that not more than 2% was observed in the spherical cell for an applied field of 1V/m to 10nm thick cell membranes. |
| first_indexed | 2024-03-05T18:44:34Z |
| format | Book Section |
| id | utm.eprints-29358 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T18:44:34Z |
| publishDate | 2011 |
| publisher | Springer Berlin Heidelberg |
| record_format | dspace |
| spelling | utm.eprints-293582017-02-04T08:39:02Z http://eprints.utm.my/29358/ Microdosimetry modeling technique for spherical cell Nazib Adon, M. Noh Dalimin, M. Mohd. Kassim, Norazan Abdul Jamil, M. M. TK Electrical engineering. Electronics Nuclear engineering Electroporation is a process of the bio-physical effect on cells exposed to an external electrical field is gaining applications in medical treatments, especially to create pores through a cell membrane and allow uptake of DNA into a cell. The efficacy of this treatment depends on the magnitude and the distribution of electric field applied, in addition to the physiological parameters, such as the conductivities and relative permittivities of the cell membranes and cytoplasm. In addition, physical parameters, such as the thickness and size of the cell also influence the efficiency of the electroporation technique. In this research, the electric field distributions of spherical cells were studied using Finite Integration Techniques (FIT), to explicate the difference in responses of the analytical and numerical cells for a given input voltage. For this purpose, quasistatic approach based on CST EM STUDIO® software was used. A comparison of the induced transmembrane potential of the analytical against numerical technique shows that not more than 2% was observed in the spherical cell for an applied field of 1V/m to 10nm thick cell membranes. Springer Berlin Heidelberg 2011 Book Section PeerReviewed Nazib Adon, M. and Noh Dalimin, M. and Mohd. Kassim, Norazan and Abdul Jamil, M. M. (2011) Microdosimetry modeling technique for spherical cell. In: 5th Kuala Lumpur International Conference on Biomedical Engineering 2011: (BIOMED 2011) 20-23 June 2011, Kuala Lumpur, Malaysia. IFMBE Proceedings, 35 . Springer Berlin Heidelberg, Germany, pp. 447-449. ISBN 978-364221728-9 http://dx.doi.org/10.1007/978-3-642-21729-6_114 10.1007/978-3-642-21729-6_114 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering Nazib Adon, M. Noh Dalimin, M. Mohd. Kassim, Norazan Abdul Jamil, M. M. Microdosimetry modeling technique for spherical cell |
| title | Microdosimetry modeling technique for spherical cell |
| title_full | Microdosimetry modeling technique for spherical cell |
| title_fullStr | Microdosimetry modeling technique for spherical cell |
| title_full_unstemmed | Microdosimetry modeling technique for spherical cell |
| title_short | Microdosimetry modeling technique for spherical cell |
| title_sort | microdosimetry modeling technique for spherical cell |
| topic | TK Electrical engineering. Electronics Nuclear engineering |
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