Bioactive polymer scaffold for fabrication of vascularized engineering tissue
Tissue engineering seeks strategies to design polymeric scaffolds that allow high-cell-density cultures with signaling molecules and suitable vascular supply. One major obstacle in tissue engineering is the inability to create thick engineered-tissue constructs. A pre-vascularized tissue scaffold ap...
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| Format: | Article |
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2012
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| _version_ | 1796858996153384960 |
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| author | Sukmana, I. |
| author_facet | Sukmana, I. |
| author_sort | Sukmana, I. |
| collection | ePrints |
| description | Tissue engineering seeks strategies to design polymeric scaffolds that allow high-cell-density cultures with signaling molecules and suitable vascular supply. One major obstacle in tissue engineering is the inability to create thick engineered-tissue constructs. A pre-vascularized tissue scaffold appears to be the most favorable approach to avoid nutrient and oxygen supply limitations as well as to allow waste removal, factors that are often hurdles in developing thick engineered tissues. Vascularization can be achieved using strategies in which cells are cultured in bioactive polymer scaffolds that can mimic extracellular matrix environments. This review addresses recent advances and future challenges in developing and using bioactive polymer scaffolds to promote tissue construct vascularization. |
| first_indexed | 2024-03-05T19:20:39Z |
| format | Article |
| id | utm.eprints-46650 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:20:39Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | utm.eprints-466502017-09-17T08:57:59Z http://eprints.utm.my/46650/ Bioactive polymer scaffold for fabrication of vascularized engineering tissue Sukmana, I. RD Surgery Tissue engineering seeks strategies to design polymeric scaffolds that allow high-cell-density cultures with signaling molecules and suitable vascular supply. One major obstacle in tissue engineering is the inability to create thick engineered-tissue constructs. A pre-vascularized tissue scaffold appears to be the most favorable approach to avoid nutrient and oxygen supply limitations as well as to allow waste removal, factors that are often hurdles in developing thick engineered tissues. Vascularization can be achieved using strategies in which cells are cultured in bioactive polymer scaffolds that can mimic extracellular matrix environments. This review addresses recent advances and future challenges in developing and using bioactive polymer scaffolds to promote tissue construct vascularization. 2012 Article PeerReviewed Sukmana, I. (2012) Bioactive polymer scaffold for fabrication of vascularized engineering tissue. Journal of Artificial Organs, 15 (3). pp. 215-224. ISSN 1434-7229 http://dx.doi.org/10.1007/s10047-012-0644-6 |
| spellingShingle | RD Surgery Sukmana, I. Bioactive polymer scaffold for fabrication of vascularized engineering tissue |
| title | Bioactive polymer scaffold for fabrication of vascularized engineering tissue |
| title_full | Bioactive polymer scaffold for fabrication of vascularized engineering tissue |
| title_fullStr | Bioactive polymer scaffold for fabrication of vascularized engineering tissue |
| title_full_unstemmed | Bioactive polymer scaffold for fabrication of vascularized engineering tissue |
| title_short | Bioactive polymer scaffold for fabrication of vascularized engineering tissue |
| title_sort | bioactive polymer scaffold for fabrication of vascularized engineering tissue |
| topic | RD Surgery |
| work_keys_str_mv | AT sukmanai bioactivepolymerscaffoldforfabricationofvascularizedengineeringtissue |