Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 f...
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| Format: | Article |
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The Royal Society of Chemistry
2012
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| _version_ | 1796859105947680768 |
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| author | Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L. |
| author_facet | Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L. |
| author_sort | Dev, Selvi |
| collection | ePrints |
| description | Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin. |
| first_indexed | 2024-03-05T19:22:16Z |
| format | Article |
| id | utm.eprints-47211 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:22:16Z |
| publishDate | 2012 |
| publisher | The Royal Society of Chemistry |
| record_format | dspace |
| spelling | utm.eprints-472112019-03-31T08:34:51Z http://eprints.utm.my/47211/ Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L. TA Engineering (General). Civil engineering (General) Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin. The Royal Society of Chemistry 2012 Article PeerReviewed Dev, Selvi and Prabhakaran, Praseetha and Filgueira, Luis and Iyer, K. Swaminathan and Raston, Colin L. (2012) Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent. Nanoscale, 4 (8). pp. 2575-2579. ISSN 2040-3364 http://dx.doi.org/10.1039/c2nr11502f DOI:10.1039/c2nr11502f |
| spellingShingle | TA Engineering (General). Civil engineering (General) Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L. Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent |
| title | Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent |
| title_full | Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent |
| title_fullStr | Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent |
| title_full_unstemmed | Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent |
| title_short | Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent |
| title_sort | microfluidic fabrication of cationic curcumin nanoparticles as an anti cancer agent |
| topic | TA Engineering (General). Civil engineering (General) |
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