Overview on design considerations for development of disposable microbiorector prototypes
Microbioreactors are a miniaturized scale bioreactor system normally designed for bioprocess development. Such a microbioreactor design offer a new platform in carrying out cheap fermentation experiments under well controlled conditions – comparable to that of typical bench scale bioreactors. Additi...
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| Format: | Article |
| Language: | English |
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Penerbit UTM Press
2012
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| Online Access: | http://eprints.utm.my/47342/1/MuhdNazrulZainalAlam2012_OverviewonDesignConsiderationsforDevelopment.pdf |
| _version_ | 1796859128898912256 |
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| author | Alam, M. N. H. Z. Zainal Alam, Muhd. Nazrul Hisham Gernaey, Krist V. |
| author_facet | Alam, M. N. H. Z. Zainal Alam, Muhd. Nazrul Hisham Gernaey, Krist V. |
| author_sort | Alam, M. N. H. Z. |
| collection | ePrints |
| description | Microbioreactors are a miniaturized scale bioreactor system normally designed for bioprocess development. Such a microbioreactor design offer a new platform in carrying out cheap fermentation experiments under well controlled conditions – comparable to that of typical bench scale bioreactors. Additionally, by adapting polymer technology, microbioreactor can for example be made disposable. Thus, eliminates the need for cleaning of the reactor at the end of every experiment. Since typical working volumes of microbioreactors are less than 1 mL, this furthermore reduces substrate and utility consumption per experiment. Additionally, often a microbioreactor system is interfaced with optical measurements to acquire a real-time experimental data and thus, increases the amount of information gained per experiment. To design a microbioreactor system, one must consider the design of the entire system that drives the reactor and not just restrict the design only to the mechanical aspects of the reactor. In this paper, important design considerations as well as technical challenges for establishment of a microbioreactor to facilitate a typical aerobic fermentation processes are discussed. These include reactor operating feature and size, reactor mechanics (materials, fabrications, and mixing), reactor fluidics (connections, aeration, evaporation and feeding strategy), process control of physical parameters (temperature, pH, and dissolved oxygen level) and detection methods for measuring the cells concentration. |
| first_indexed | 2024-03-05T19:22:36Z |
| format | Article |
| id | utm.eprints-47342 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T19:22:36Z |
| publishDate | 2012 |
| publisher | Penerbit UTM Press |
| record_format | dspace |
| spelling | utm.eprints-473422019-04-25T01:18:31Z http://eprints.utm.my/47342/ Overview on design considerations for development of disposable microbiorector prototypes Alam, M. N. H. Z. Zainal Alam, Muhd. Nazrul Hisham Gernaey, Krist V. TK Electrical engineering. Electronics Nuclear engineering Microbioreactors are a miniaturized scale bioreactor system normally designed for bioprocess development. Such a microbioreactor design offer a new platform in carrying out cheap fermentation experiments under well controlled conditions – comparable to that of typical bench scale bioreactors. Additionally, by adapting polymer technology, microbioreactor can for example be made disposable. Thus, eliminates the need for cleaning of the reactor at the end of every experiment. Since typical working volumes of microbioreactors are less than 1 mL, this furthermore reduces substrate and utility consumption per experiment. Additionally, often a microbioreactor system is interfaced with optical measurements to acquire a real-time experimental data and thus, increases the amount of information gained per experiment. To design a microbioreactor system, one must consider the design of the entire system that drives the reactor and not just restrict the design only to the mechanical aspects of the reactor. In this paper, important design considerations as well as technical challenges for establishment of a microbioreactor to facilitate a typical aerobic fermentation processes are discussed. These include reactor operating feature and size, reactor mechanics (materials, fabrications, and mixing), reactor fluidics (connections, aeration, evaporation and feeding strategy), process control of physical parameters (temperature, pH, and dissolved oxygen level) and detection methods for measuring the cells concentration. Penerbit UTM Press 2012 Article PeerReviewed application/pdf en http://eprints.utm.my/47342/1/MuhdNazrulZainalAlam2012_OverviewonDesignConsiderationsforDevelopment.pdf Alam, M. N. H. Z. and Zainal Alam, Muhd. Nazrul Hisham and Gernaey, Krist V. (2012) Overview on design considerations for development of disposable microbiorector prototypes. Jurnal Teknologi (Sciences and Engineering), 59 . pp. 53-60. ISSN 0127-9696 https://jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/1268/1361 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering Alam, M. N. H. Z. Zainal Alam, Muhd. Nazrul Hisham Gernaey, Krist V. Overview on design considerations for development of disposable microbiorector prototypes |
| title | Overview on design considerations for development of disposable microbiorector prototypes |
| title_full | Overview on design considerations for development of disposable microbiorector prototypes |
| title_fullStr | Overview on design considerations for development of disposable microbiorector prototypes |
| title_full_unstemmed | Overview on design considerations for development of disposable microbiorector prototypes |
| title_short | Overview on design considerations for development of disposable microbiorector prototypes |
| title_sort | overview on design considerations for development of disposable microbiorector prototypes |
| topic | TK Electrical engineering. Electronics Nuclear engineering |
| url | http://eprints.utm.my/47342/1/MuhdNazrulZainalAlam2012_OverviewonDesignConsiderationsforDevelopment.pdf |
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