Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone
Synthetic compounds 3',4'-dihydroxy-7-methoxyflavone (DHMF) and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone (HTMC) were investigated for their antioxidant and anti-tyrosinase activities. Antioxidant activities were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radica...
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| Format: | Article |
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American Scientific Publishers
2013
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| _version_ | 1796859438484684800 |
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| author | Ahmad, N. A. Nordin, N. H. Nadri, Muhammad Helmi Mohamed Zulkifli, Razauden Ahmad, Farediah Mohd. Sirat, Hasnah |
| author_facet | Ahmad, N. A. Nordin, N. H. Nadri, Muhammad Helmi Mohamed Zulkifli, Razauden Ahmad, Farediah Mohd. Sirat, Hasnah |
| author_sort | Ahmad, N. A. |
| collection | ePrints |
| description | Synthetic compounds 3',4'-dihydroxy-7-methoxyflavone (DHMF) and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone (HTMC) were investigated for their antioxidant and anti-tyrosinase activities. Antioxidant activities were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and Ferric Reducing Ability of Plasma (FRAP) assay. DHMF possessed antioxidant activities with no activity detected for HTMC. Further investigation demonstrates that DHMF possessed greater antioxidant capacity at longer incubation time compared to L-ascorbic acid. In contrast, HTMC demonstrates a novel anti-tyrosinase activity with no activity observed for DHMF. Evaluation on cytotoxicity effects revealed that both synthetic compounds inhibit the viability of CHO and HeLa cells in a concentration-dependent manner with no effect detected at low concentration. |
| first_indexed | 2024-03-05T19:27:11Z |
| format | Article |
| id | utm.eprints-49497 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:27:11Z |
| publishDate | 2013 |
| publisher | American Scientific Publishers |
| record_format | dspace |
| spelling | utm.eprints-494972018-11-30T06:55:24Z http://eprints.utm.my/49497/ Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone Ahmad, N. A. Nordin, N. H. Nadri, Muhammad Helmi Mohamed Zulkifli, Razauden Ahmad, Farediah Mohd. Sirat, Hasnah QP Physiology Synthetic compounds 3',4'-dihydroxy-7-methoxyflavone (DHMF) and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone (HTMC) were investigated for their antioxidant and anti-tyrosinase activities. Antioxidant activities were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and Ferric Reducing Ability of Plasma (FRAP) assay. DHMF possessed antioxidant activities with no activity detected for HTMC. Further investigation demonstrates that DHMF possessed greater antioxidant capacity at longer incubation time compared to L-ascorbic acid. In contrast, HTMC demonstrates a novel anti-tyrosinase activity with no activity observed for DHMF. Evaluation on cytotoxicity effects revealed that both synthetic compounds inhibit the viability of CHO and HeLa cells in a concentration-dependent manner with no effect detected at low concentration. American Scientific Publishers 2013 Article PeerReviewed Ahmad, N. A. and Nordin, N. H. and Nadri, Muhammad Helmi and Mohamed Zulkifli, Razauden and Ahmad, Farediah and Mohd. Sirat, Hasnah (2013) Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone. Advanced Science Letters, 19 (12). pp. 3628-3631. ISSN 1936-6612 http://dx.doi.org/10.1166/asl.2013.5218 DOI: 10.1166/asl.2013.5218 |
| spellingShingle | QP Physiology Ahmad, N. A. Nordin, N. H. Nadri, Muhammad Helmi Mohamed Zulkifli, Razauden Ahmad, Farediah Mohd. Sirat, Hasnah Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone |
| title | Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone |
| title_full | Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone |
| title_fullStr | Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone |
| title_full_unstemmed | Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone |
| title_short | Bioactivities and cytotoxicities effects of 3',4'-dihydroxy-7-methoxyflavone and 2'-hydroxy-3,4,3',4'-tetramethoxychalcone |
| title_sort | bioactivities and cytotoxicities effects of 3 4 dihydroxy 7 methoxyflavone and 2 hydroxy 3 4 3 4 tetramethoxychalcone |
| topic | QP Physiology |
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