Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process
The present study reports a relatively simple method for the synthesis of stable silver substituted hydroxyapatite nanoparticles with controlled morphology and particle size. In order to achieve this, CTAB is included as a surfactant in the microwave refluxing process (600 W for 7 min). The nanopart...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier Ltd.
2013
|
| Subjects: |
| _version_ | 1796859473085595648 |
|---|---|
| author | Iqbal, Nida Abdul Kadir, Mohammed Rafiq Nik Malek, Nik Ahmad Nazim Mahmood, Nasrul Humaimi Murali, Malliga Raman Tunku Zainol Abidin, Tunku Kamarul Zaman |
| author_facet | Iqbal, Nida Abdul Kadir, Mohammed Rafiq Nik Malek, Nik Ahmad Nazim Mahmood, Nasrul Humaimi Murali, Malliga Raman Tunku Zainol Abidin, Tunku Kamarul Zaman |
| author_sort | Iqbal, Nida |
| collection | ePrints |
| description | The present study reports a relatively simple method for the synthesis of stable silver substituted hydroxyapatite nanoparticles with controlled morphology and particle size. In order to achieve this, CTAB is included as a surfactant in the microwave refluxing process (600 W for 7 min). The nanoparticles produced with different silver ion concentrations (0.05, 0.1 and 0.2 wt%) were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscope (FESEM), energy dispersive X-ray (EDX) and Brunauer-Emmett-Teller (BET) analysis. XRD and FTIR analyses reveal that the Ag-HA nanoparticles were phase pure at 1000 C. FESEM images showed that the produced nanoparticles are in the size range of 58-72 nm and exert uniform elongated spheroid morphology. The dielectric properties suggest that the increase in dielectric constant (É′) and dissipation factor (D) values with increasing Ag concentrations. Antibacterial performance of the Ag-HA samples elucidated using disk diffusion technique (DDT) and minimum inhibitory concentration (MIC) demonstrates anti-bacterial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli. This effect was dose dependent and was more pronounced against Gram-negative bacteria than Gram-positive organisms. |
| first_indexed | 2024-03-05T19:27:41Z |
| format | Article |
| id | utm.eprints-50218 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:27:41Z |
| publishDate | 2013 |
| publisher | Elsevier Ltd. |
| record_format | dspace |
| spelling | utm.eprints-502182018-11-30T06:55:32Z http://eprints.utm.my/50218/ Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process Iqbal, Nida Abdul Kadir, Mohammed Rafiq Nik Malek, Nik Ahmad Nazim Mahmood, Nasrul Humaimi Murali, Malliga Raman Tunku Zainol Abidin, Tunku Kamarul Zaman R Medicine (General) The present study reports a relatively simple method for the synthesis of stable silver substituted hydroxyapatite nanoparticles with controlled morphology and particle size. In order to achieve this, CTAB is included as a surfactant in the microwave refluxing process (600 W for 7 min). The nanoparticles produced with different silver ion concentrations (0.05, 0.1 and 0.2 wt%) were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscope (FESEM), energy dispersive X-ray (EDX) and Brunauer-Emmett-Teller (BET) analysis. XRD and FTIR analyses reveal that the Ag-HA nanoparticles were phase pure at 1000 C. FESEM images showed that the produced nanoparticles are in the size range of 58-72 nm and exert uniform elongated spheroid morphology. The dielectric properties suggest that the increase in dielectric constant (É′) and dissipation factor (D) values with increasing Ag concentrations. Antibacterial performance of the Ag-HA samples elucidated using disk diffusion technique (DDT) and minimum inhibitory concentration (MIC) demonstrates anti-bacterial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli. This effect was dose dependent and was more pronounced against Gram-negative bacteria than Gram-positive organisms. Elsevier Ltd. 2013 Article PeerReviewed Iqbal, Nida and Abdul Kadir, Mohammed Rafiq and Nik Malek, Nik Ahmad Nazim and Mahmood, Nasrul Humaimi and Murali, Malliga Raman and Tunku Zainol Abidin, Tunku Kamarul Zaman (2013) Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process. Materials Research Bulletin, 48 (9). pp. 3172-3177. ISSN 0025-5408 http://dx.doi.org/10.1016/j.materresbull.2013.04.068 DOI: 10.1016/j.materresbull.2013.04.068 |
| spellingShingle | R Medicine (General) Iqbal, Nida Abdul Kadir, Mohammed Rafiq Nik Malek, Nik Ahmad Nazim Mahmood, Nasrul Humaimi Murali, Malliga Raman Tunku Zainol Abidin, Tunku Kamarul Zaman Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process |
| title | Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process |
| title_full | Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process |
| title_fullStr | Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process |
| title_full_unstemmed | Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process |
| title_short | Characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process |
| title_sort | characterization and antibacterial properties of stable silver substituted hydroxyapatite nanoparticles synthesized through surfactant assisted microwave process |
| topic | R Medicine (General) |
| work_keys_str_mv | AT iqbalnida characterizationandantibacterialpropertiesofstablesilversubstitutedhydroxyapatitenanoparticlessynthesizedthroughsurfactantassistedmicrowaveprocess AT abdulkadirmohammedrafiq characterizationandantibacterialpropertiesofstablesilversubstitutedhydroxyapatitenanoparticlessynthesizedthroughsurfactantassistedmicrowaveprocess AT nikmaleknikahmadnazim characterizationandantibacterialpropertiesofstablesilversubstitutedhydroxyapatitenanoparticlessynthesizedthroughsurfactantassistedmicrowaveprocess AT mahmoodnasrulhumaimi characterizationandantibacterialpropertiesofstablesilversubstitutedhydroxyapatitenanoparticlessynthesizedthroughsurfactantassistedmicrowaveprocess AT muralimalligaraman characterizationandantibacterialpropertiesofstablesilversubstitutedhydroxyapatitenanoparticlessynthesizedthroughsurfactantassistedmicrowaveprocess AT tunkuzainolabidintunkukamarulzaman characterizationandantibacterialpropertiesofstablesilversubstitutedhydroxyapatitenanoparticlessynthesizedthroughsurfactantassistedmicrowaveprocess |