Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review
Single cell mass (SCM) is one of the intrinsic properties of cell and is a vital part of single cell analysis (SCA). To date, a myriad numbers of works has been successfully reported for single cell mass measurement but the reported information are scattered, consequently a comprehensive review beco...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Penerbit UTM
2014
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| Online Access: | http://eprints.utm.my/53291/1/Md.HabiburRahman2014_Lab-on-chipmicrofluidicssystem.pdf |
| _version_ | 1796859824086974464 |
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| author | Rahman, Md. Habibur A. Ahmad, Mohd. Ridzuan |
| author_facet | Rahman, Md. Habibur A. Ahmad, Mohd. Ridzuan |
| author_sort | Rahman, Md. Habibur A. |
| collection | ePrints |
| description | Single cell mass (SCM) is one of the intrinsic properties of cell and is a vital part of single cell analysis (SCA). To date, a myriad numbers of works has been successfully reported for single cell mass measurement but the reported information are scattered, consequently a comprehensive review becomes mandatory to bring them together. Lab-on-chip microfluidics system integrated with micro-resonator provided an excellent platform to measure single cell mass directly (in presence of cells). On-chip microfluidics system like suspended micro channel resonator (SMR) was reported for non-adherent single yeast cell mass while 'living cantilever arrays' (LCA) was proposed to measure adherent HeLa cell mass. On the other hand, cantilever based resonant mass measurement system has non-uniform mass sensitivity; this issue has been overcome by pedestal mass measurement system (PMMS). PMMS has a unique geometrical structure that provided uniform mass sensitivity to the sensing surface. Moreover, we presented a comprehensive discussion of each of the available methods of SCM elaborating the sensing mechanism, geometry of the sensor and governing equations. It is hoped that, information presented in this comprehensive review paper will be a valuable source for the single cell mass analysers and biological researchers |
| first_indexed | 2024-03-05T19:32:56Z |
| format | Article |
| id | utm.eprints-53291 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T19:32:56Z |
| publishDate | 2014 |
| publisher | Penerbit UTM |
| record_format | dspace |
| spelling | utm.eprints-532912018-07-25T07:55:24Z http://eprints.utm.my/53291/ Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review Rahman, Md. Habibur A. Ahmad, Mohd. Ridzuan TK Electrical engineering. Electronics Nuclear engineering Single cell mass (SCM) is one of the intrinsic properties of cell and is a vital part of single cell analysis (SCA). To date, a myriad numbers of works has been successfully reported for single cell mass measurement but the reported information are scattered, consequently a comprehensive review becomes mandatory to bring them together. Lab-on-chip microfluidics system integrated with micro-resonator provided an excellent platform to measure single cell mass directly (in presence of cells). On-chip microfluidics system like suspended micro channel resonator (SMR) was reported for non-adherent single yeast cell mass while 'living cantilever arrays' (LCA) was proposed to measure adherent HeLa cell mass. On the other hand, cantilever based resonant mass measurement system has non-uniform mass sensitivity; this issue has been overcome by pedestal mass measurement system (PMMS). PMMS has a unique geometrical structure that provided uniform mass sensitivity to the sensing surface. Moreover, we presented a comprehensive discussion of each of the available methods of SCM elaborating the sensing mechanism, geometry of the sensor and governing equations. It is hoped that, information presented in this comprehensive review paper will be a valuable source for the single cell mass analysers and biological researchers Penerbit UTM 2014 Article PeerReviewed application/pdf en http://eprints.utm.my/53291/1/Md.HabiburRahman2014_Lab-on-chipmicrofluidicssystem.pdf Rahman, Md. Habibur A. and Ahmad, Mohd. Ridzuan (2014) Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review. Jurnal Teknologi (Sciences and Engineering), 69 (8). pp. 85-93. ISSN 0127-9696 http://dx.doi.org/10.11113/jt.v69.3301 DOI: 10.11113/jt.v69.3301 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering Rahman, Md. Habibur A. Ahmad, Mohd. Ridzuan Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review |
| title | Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review |
| title_full | Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review |
| title_fullStr | Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review |
| title_full_unstemmed | Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review |
| title_short | Lab-on-chip microfluidics system for single cell mass measurement: a comprehensive review |
| title_sort | lab on chip microfluidics system for single cell mass measurement a comprehensive review |
| topic | TK Electrical engineering. Electronics Nuclear engineering |
| url | http://eprints.utm.my/53291/1/Md.HabiburRahman2014_Lab-on-chipmicrofluidicssystem.pdf |
| work_keys_str_mv | AT rahmanmdhabibura labonchipmicrofluidicssystemforsinglecellmassmeasurementacomprehensivereview AT ahmadmohdridzuan labonchipmicrofluidicssystemforsinglecellmassmeasurementacomprehensivereview |