Formulation and evaluation of Ketoconazole polymeric films for topical application
The objective of the current paper was to prepare and evaluate various polymeric films for fungal infection treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as antifungal drug were prepared by solvent casting technique. The prepared films wer...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Open Science Publishers LLP Inc.
2015
|
| Subjects: |
| _version_ | 1796860138699620352 |
|---|---|
| author | Salama, Mohamed Mahdy, Mahmoud Abd. Elghany Mohamed, Amina Mohamed, Aref T. Keleb, Eseldin I. Omar, Assad A. Elmarzugi, Nagib Ali |
| author_facet | Salama, Mohamed Mahdy, Mahmoud Abd. Elghany Mohamed, Amina Mohamed, Aref T. Keleb, Eseldin I. Omar, Assad A. Elmarzugi, Nagib Ali |
| author_sort | Salama, Mohamed |
| collection | ePrints |
| description | The objective of the current paper was to prepare and evaluate various polymeric films for fungal infection treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as antifungal drug were prepared by solvent casting technique. The prepared films were tested for their physico-mechanical properties as tensile strength, physical endurance, elasticity, water vapor permeation and water loss. The release of ketoconazole from the prepared medicated films was examined. It is involved 20 volunteers suffering from legs fungal infection. Ten of the patients used the films and a follow up study was carried out for 14 days, in comparison with other patients who applied ketoconazole medicated ointment, cream gel and Emulgel. The results revealed that films prepared with Eudragit RL 100 containing glyceryl triacetate produced maximum release of ketoconazole both In vitro and In vivo as compared with other topical dosage forms as ointment, cream, gel and Emulgel. Moreover, the films constitute a simple and convenient method for treatment of various fungal infections. As conclusion, the use of antifungal drugs such as Ketoconazole incorporated in polymeric films, the output results provided promised evidence in the treatment of dermatophytosis |
| first_indexed | 2024-03-05T19:37:29Z |
| format | Article |
| id | utm.eprints-55373 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:37:29Z |
| publishDate | 2015 |
| publisher | Open Science Publishers LLP Inc. |
| record_format | dspace |
| spelling | utm.eprints-553732017-02-15T06:51:48Z http://eprints.utm.my/55373/ Formulation and evaluation of Ketoconazole polymeric films for topical application Salama, Mohamed Mahdy, Mahmoud Abd. Elghany Mohamed, Amina Mohamed, Aref T. Keleb, Eseldin I. Omar, Assad A. Elmarzugi, Nagib Ali TP Chemical technology The objective of the current paper was to prepare and evaluate various polymeric films for fungal infection treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as antifungal drug were prepared by solvent casting technique. The prepared films were tested for their physico-mechanical properties as tensile strength, physical endurance, elasticity, water vapor permeation and water loss. The release of ketoconazole from the prepared medicated films was examined. It is involved 20 volunteers suffering from legs fungal infection. Ten of the patients used the films and a follow up study was carried out for 14 days, in comparison with other patients who applied ketoconazole medicated ointment, cream gel and Emulgel. The results revealed that films prepared with Eudragit RL 100 containing glyceryl triacetate produced maximum release of ketoconazole both In vitro and In vivo as compared with other topical dosage forms as ointment, cream, gel and Emulgel. Moreover, the films constitute a simple and convenient method for treatment of various fungal infections. As conclusion, the use of antifungal drugs such as Ketoconazole incorporated in polymeric films, the output results provided promised evidence in the treatment of dermatophytosis Open Science Publishers LLP Inc. 2015 Article PeerReviewed Salama, Mohamed and Mahdy, Mahmoud Abd. Elghany and Mohamed, Amina and Mohamed, Aref T. and Keleb, Eseldin I. and Omar, Assad A. and Elmarzugi, Nagib Ali (2015) Formulation and evaluation of Ketoconazole polymeric films for topical application. Journal of Applied Pharmaceutical Science, 5 (5). pp. 28-32. ISSN 2231-3354 http://dx.doi.org/10.7324/JAPS.2015.50505 |
| spellingShingle | TP Chemical technology Salama, Mohamed Mahdy, Mahmoud Abd. Elghany Mohamed, Amina Mohamed, Aref T. Keleb, Eseldin I. Omar, Assad A. Elmarzugi, Nagib Ali Formulation and evaluation of Ketoconazole polymeric films for topical application |
| title | Formulation and evaluation of Ketoconazole polymeric films for topical application |
| title_full | Formulation and evaluation of Ketoconazole polymeric films for topical application |
| title_fullStr | Formulation and evaluation of Ketoconazole polymeric films for topical application |
| title_full_unstemmed | Formulation and evaluation of Ketoconazole polymeric films for topical application |
| title_short | Formulation and evaluation of Ketoconazole polymeric films for topical application |
| title_sort | formulation and evaluation of ketoconazole polymeric films for topical application |
| topic | TP Chemical technology |
| work_keys_str_mv | AT salamamohamed formulationandevaluationofketoconazolepolymericfilmsfortopicalapplication AT mahdymahmoudabdelghany formulationandevaluationofketoconazolepolymericfilmsfortopicalapplication AT mohamedamina formulationandevaluationofketoconazolepolymericfilmsfortopicalapplication AT mohamedareft formulationandevaluationofketoconazolepolymericfilmsfortopicalapplication AT kelebeseldini formulationandevaluationofketoconazolepolymericfilmsfortopicalapplication AT omarassada formulationandevaluationofketoconazolepolymericfilmsfortopicalapplication AT elmarzuginagibali formulationandevaluationofketoconazolepolymericfilmsfortopicalapplication |