Heterocyclic scaffolds: centrality in anticancer drug development
Cancer has been cursed for human beings for long time. Millions people lost their lives due to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal propertie...
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| Format: | Article |
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Bentham Science Publishers
2015
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| author | Ali, Imran Lone, Mohammad Nadeem Al-Othman, Zeid Abdullah Al-Warthan, Abdulrahman Sanagi, Mohd. Marsin |
| author_facet | Ali, Imran Lone, Mohammad Nadeem Al-Othman, Zeid Abdullah Al-Warthan, Abdulrahman Sanagi, Mohd. Marsin |
| author_sort | Ali, Imran |
| collection | ePrints |
| description | Cancer has been cursed for human beings for long time. Millions people lost their lives due to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal properties including anticancer. Some market selling heterocyclic anticancer drugs include 5-flourouracil, methortrexate, doxorubicin, daunorubicin, etc. Besides, some natural products such as vinblastine and vincristine are also used as anticancer drugs. Overall, heterocyclic moeities have always been core parts in the expansion of anticancer drugs. This article describes the importance of heterocyclic nuclei in the development of anticancer drugs. Besides, the attempts have been made to discuss both naturally occurring and synthetic heterocyclic compounds as anticancer agents. In addition, some market selling anticancer heterocyclic compounds have been described. Moreover, the efforts have been made to discuss the mechanisms of actions and recent advances in heterocyclic compounds as anticancer agents. The current challenges and future prospectives of heterocyclic compounds have also been discussed. Finally, the suggestions for syntheses of effective, selective, fast and human friendly anticancer agents are discussed into the different sections |
| first_indexed | 2024-03-05T19:38:03Z |
| format | Article |
| id | utm.eprints-55564 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:38:03Z |
| publishDate | 2015 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | utm.eprints-555642017-02-15T04:36:33Z http://eprints.utm.my/55564/ Heterocyclic scaffolds: centrality in anticancer drug development Ali, Imran Lone, Mohammad Nadeem Al-Othman, Zeid Abdullah Al-Warthan, Abdulrahman Sanagi, Mohd. Marsin QD Chemistry Cancer has been cursed for human beings for long time. Millions people lost their lives due to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal properties including anticancer. Some market selling heterocyclic anticancer drugs include 5-flourouracil, methortrexate, doxorubicin, daunorubicin, etc. Besides, some natural products such as vinblastine and vincristine are also used as anticancer drugs. Overall, heterocyclic moeities have always been core parts in the expansion of anticancer drugs. This article describes the importance of heterocyclic nuclei in the development of anticancer drugs. Besides, the attempts have been made to discuss both naturally occurring and synthetic heterocyclic compounds as anticancer agents. In addition, some market selling anticancer heterocyclic compounds have been described. Moreover, the efforts have been made to discuss the mechanisms of actions and recent advances in heterocyclic compounds as anticancer agents. The current challenges and future prospectives of heterocyclic compounds have also been discussed. Finally, the suggestions for syntheses of effective, selective, fast and human friendly anticancer agents are discussed into the different sections Bentham Science Publishers 2015-08 Article PeerReviewed Ali, Imran and Lone, Mohammad Nadeem and Al-Othman, Zeid Abdullah and Al-Warthan, Abdulrahman and Sanagi, Mohd. Marsin (2015) Heterocyclic scaffolds: centrality in anticancer drug development. Current Drug Targets, 6 (7). pp. 711-734. ISSN 1389-4501 |
| spellingShingle | QD Chemistry Ali, Imran Lone, Mohammad Nadeem Al-Othman, Zeid Abdullah Al-Warthan, Abdulrahman Sanagi, Mohd. Marsin Heterocyclic scaffolds: centrality in anticancer drug development |
| title | Heterocyclic scaffolds: centrality in anticancer drug development |
| title_full | Heterocyclic scaffolds: centrality in anticancer drug development |
| title_fullStr | Heterocyclic scaffolds: centrality in anticancer drug development |
| title_full_unstemmed | Heterocyclic scaffolds: centrality in anticancer drug development |
| title_short | Heterocyclic scaffolds: centrality in anticancer drug development |
| title_sort | heterocyclic scaffolds centrality in anticancer drug development |
| topic | QD Chemistry |
| work_keys_str_mv | AT aliimran heterocyclicscaffoldscentralityinanticancerdrugdevelopment AT lonemohammadnadeem heterocyclicscaffoldscentralityinanticancerdrugdevelopment AT alothmanzeidabdullah heterocyclicscaffoldscentralityinanticancerdrugdevelopment AT alwarthanabdulrahman heterocyclicscaffoldscentralityinanticancerdrugdevelopment AT sanagimohdmarsin heterocyclicscaffoldscentralityinanticancerdrugdevelopment |