Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes
Heterocyclic chalcones containing halogenated thiophenes were synthesized. The first step was to synthesize 3-acetyl-2,5-dichlorothiophene and 2-acetyl-5-chlorothiophene as heterocyclic ketones by using Friedel-Crafts acylation. The ketones were then used to synthesize thiophene chalcones through Cl...
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| Format: | Article |
| Language: | English |
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Penerbit UTM Press
2015
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| Online Access: | http://eprints.utm.my/55599/1/JoazaizulfazliJamalis2015_SynthesisandCharacterizationofHaterocyclicChalcones.pdf |
| _version_ | 1796860184064163840 |
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| author | Al-Maqtari, Helmi Mohammed Jamalis, Joazaizulfazli Mohd. Sirat, Hasnah |
| author_facet | Al-Maqtari, Helmi Mohammed Jamalis, Joazaizulfazli Mohd. Sirat, Hasnah |
| author_sort | Al-Maqtari, Helmi Mohammed |
| collection | ePrints |
| description | Heterocyclic chalcones containing halogenated thiophenes were synthesized. The first step was to synthesize 3-acetyl-2,5-dichlorothiophene and 2-acetyl-5-chlorothiophene as heterocyclic ketones by using Friedel-Crafts acylation. The ketones were then used to synthesize thiophene chalcones through Claisen-Schmidt reaction with the respective heterocyclic aldehydes such as 5-bromothiophene-2-carbaldehyde, 3-methyl-2-thiophene carboxaldehyde and 2-thiophene carboxaldehyde with 3-acetyl-2,5-dichlorothiophene or 2-acetyl-5-chlorothiophene in presence of basic medium, sodium hydroxide to form the corresponding chalcones. Structures of the synthetic compounds were confirmed by IR, MS, 1H and 13C NMR spectral data. |
| first_indexed | 2024-03-05T19:38:09Z |
| format | Article |
| id | utm.eprints-55599 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T19:38:09Z |
| publishDate | 2015 |
| publisher | Penerbit UTM Press |
| record_format | dspace |
| spelling | utm.eprints-555992017-11-01T04:16:58Z http://eprints.utm.my/55599/ Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes Al-Maqtari, Helmi Mohammed Jamalis, Joazaizulfazli Mohd. Sirat, Hasnah QD Chemistry Heterocyclic chalcones containing halogenated thiophenes were synthesized. The first step was to synthesize 3-acetyl-2,5-dichlorothiophene and 2-acetyl-5-chlorothiophene as heterocyclic ketones by using Friedel-Crafts acylation. The ketones were then used to synthesize thiophene chalcones through Claisen-Schmidt reaction with the respective heterocyclic aldehydes such as 5-bromothiophene-2-carbaldehyde, 3-methyl-2-thiophene carboxaldehyde and 2-thiophene carboxaldehyde with 3-acetyl-2,5-dichlorothiophene or 2-acetyl-5-chlorothiophene in presence of basic medium, sodium hydroxide to form the corresponding chalcones. Structures of the synthetic compounds were confirmed by IR, MS, 1H and 13C NMR spectral data. Penerbit UTM Press 2015 Article PeerReviewed application/pdf en http://eprints.utm.my/55599/1/JoazaizulfazliJamalis2015_SynthesisandCharacterizationofHaterocyclicChalcones.pdf Al-Maqtari, Helmi Mohammed and Jamalis, Joazaizulfazli and Mohd. Sirat, Hasnah (2015) Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes. Jurnal Teknologi, 77 (3). pp. 55-59. ISSN 0127-9696 http://dx.doi.org/10.11113/jt.v77.6005 DOI:10.11113/jt.v77.6005 |
| spellingShingle | QD Chemistry Al-Maqtari, Helmi Mohammed Jamalis, Joazaizulfazli Mohd. Sirat, Hasnah Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes |
| title | Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes |
| title_full | Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes |
| title_fullStr | Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes |
| title_full_unstemmed | Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes |
| title_short | Synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes |
| title_sort | synthesis and characterization of heterocyclic chalcones containing halogenated thiophenes |
| topic | QD Chemistry |
| url | http://eprints.utm.my/55599/1/JoazaizulfazliJamalis2015_SynthesisandCharacterizationofHaterocyclicChalcones.pdf |
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