Usage of sugar ester in the preparation of avocado oil nanoemulsion
Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable droplet size, long-te...
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| Format: | Article |
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Asian Journal of Pharmaceutical and Clinical Research
2015
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| _version_ | 1796860288505479168 |
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| author | Elmarzugi, Nagib Ali Eid, Ahmad Mustafa Masoud Elnattah, Nabil S. Elmahgoubi, Assad Abdul Hamid, Mariani Hasham, Rosnani Abdul-Aziz, Azila Ariffin, Farah Diana Salama, Mohamed |
| author_facet | Elmarzugi, Nagib Ali Eid, Ahmad Mustafa Masoud Elnattah, Nabil S. Elmahgoubi, Assad Abdul Hamid, Mariani Hasham, Rosnani Abdul-Aziz, Azila Ariffin, Farah Diana Salama, Mohamed |
| author_sort | Elmarzugi, Nagib Ali |
| collection | ePrints |
| description | Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal, vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits. Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three different types of sucrose esters surfactant (laureate, oleate, and palmitate). Stability study was conducted for NE at different temperatures (4°C, 25°C, and 40°C) for 6 months. Results: The NE contained sucrose laureate produced best nanosized formulations compared to other oleate and palmitate, with optimum droplet size 106 ± 1.70 nm, size distribution 0.156 ± 0.01, and zeta potential -30.4 ± 0.70. The NE formulations were very stable at 4°C compared to 25°C and 40°C while at 25°C NE showed moderate stability, but it was unstable at 40°C. Conclusion: Sucrose laureate was able to produce NE with phase inversion and self-emulsification techniques and the ideal storage condition for NE is 4°C. |
| first_indexed | 2024-03-05T19:39:08Z |
| format | Article |
| id | utm.eprints-55932 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:39:08Z |
| publishDate | 2015 |
| publisher | Asian Journal of Pharmaceutical and Clinical Research |
| record_format | dspace |
| spelling | utm.eprints-559322017-09-05T04:09:31Z http://eprints.utm.my/55932/ Usage of sugar ester in the preparation of avocado oil nanoemulsion Elmarzugi, Nagib Ali Eid, Ahmad Mustafa Masoud Elnattah, Nabil S. Elmahgoubi, Assad Abdul Hamid, Mariani Hasham, Rosnani Abdul-Aziz, Azila Ariffin, Farah Diana Salama, Mohamed RS Pharmacy and materia medica Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal, vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits. Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three different types of sucrose esters surfactant (laureate, oleate, and palmitate). Stability study was conducted for NE at different temperatures (4°C, 25°C, and 40°C) for 6 months. Results: The NE contained sucrose laureate produced best nanosized formulations compared to other oleate and palmitate, with optimum droplet size 106 ± 1.70 nm, size distribution 0.156 ± 0.01, and zeta potential -30.4 ± 0.70. The NE formulations were very stable at 4°C compared to 25°C and 40°C while at 25°C NE showed moderate stability, but it was unstable at 40°C. Conclusion: Sucrose laureate was able to produce NE with phase inversion and self-emulsification techniques and the ideal storage condition for NE is 4°C. Asian Journal of Pharmaceutical and Clinical Research 2015 Article PeerReviewed Elmarzugi, Nagib Ali and Eid, Ahmad Mustafa Masoud and Elnattah, Nabil S. and Elmahgoubi, Assad and Abdul Hamid, Mariani and Hasham, Rosnani and Abdul-Aziz, Azila and Ariffin, Farah Diana and Salama, Mohamed (2015) Usage of sugar ester in the preparation of avocado oil nanoemulsion. Asian Journal of Pharmaceutical and Clinical Research, 8 (4). pp. 66-69. ISSN 0974-2441 https://innovareacademics.in/journals/index.php/ajpcr/article/view/5285 |
| spellingShingle | RS Pharmacy and materia medica Elmarzugi, Nagib Ali Eid, Ahmad Mustafa Masoud Elnattah, Nabil S. Elmahgoubi, Assad Abdul Hamid, Mariani Hasham, Rosnani Abdul-Aziz, Azila Ariffin, Farah Diana Salama, Mohamed Usage of sugar ester in the preparation of avocado oil nanoemulsion |
| title | Usage of sugar ester in the preparation of avocado oil nanoemulsion |
| title_full | Usage of sugar ester in the preparation of avocado oil nanoemulsion |
| title_fullStr | Usage of sugar ester in the preparation of avocado oil nanoemulsion |
| title_full_unstemmed | Usage of sugar ester in the preparation of avocado oil nanoemulsion |
| title_short | Usage of sugar ester in the preparation of avocado oil nanoemulsion |
| title_sort | usage of sugar ester in the preparation of avocado oil nanoemulsion |
| topic | RS Pharmacy and materia medica |
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