Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king.
A flavonoids-rich extract and seven flavonoids from the leaves and heartwoods of A. anisophyllus Miq. and A. lowii King were investigated for their inhibitory effects against acetylcholinesterase enzyme. The flavonoids were fully characterized spectroscopically as artocarpin (1), isobavachalcone (2...
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| Format: | Article |
| Language: | English |
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Universiti Pendidikan Sultan Idris
2022
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| Online Access: | http://eprints.utm.my/56137/1/SitiAwanisAbdullahSitiMariamAbdulLathiffShajarahtunnurJamil2022_AcetylcholinesteraseActivityofCrudeExtracts.pdf |
| _version_ | 1796860329686204416 |
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| author | Jamil, Shajarahtunnur Abdul Lathiff, Siti Mariam Abdullah, Siti Awanis |
| author_facet | Jamil, Shajarahtunnur Abdul Lathiff, Siti Mariam Abdullah, Siti Awanis |
| author_sort | Jamil, Shajarahtunnur |
| collection | ePrints |
| description | A flavonoids-rich extract and seven flavonoids from the leaves and heartwoods of A. anisophyllus Miq. and A. lowii King were investigated for their inhibitory effects against acetylcholinesterase enzyme. The flavonoids were fully characterized spectroscopically as artocarpin (1), isobavachalcone (2), pyranocycloartobiloxanthone A (3), 5,7-dihydroxy-4'-methoxy-6-prenylflavanone (4), 5-hydroxy-7,8-(2,2-dimethylchromano)-4'-methoxy-flavanone (5) 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallylflavone (6) and 2',4'-dihydroxy-3,4-(2",2"-dimethylchromeno)-3'-prenyldihydrochalcone (7). Acetylcholinesterase inhibitory activity of the samples was determined using TLC plate with bioactivity staining based on the Ellman’s method. Pyranocycloartobiloxanthone A (3) exhibited an excellent inhibitory activity with detection limit at 7.81 µg/mL. |
| first_indexed | 2024-03-05T19:39:45Z |
| format | Article |
| id | utm.eprints-56137 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T19:39:45Z |
| publishDate | 2022 |
| publisher | Universiti Pendidikan Sultan Idris |
| record_format | dspace |
| spelling | utm.eprints-561372024-01-22T07:18:13Z http://eprints.utm.my/56137/ Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. Jamil, Shajarahtunnur Abdul Lathiff, Siti Mariam Abdullah, Siti Awanis Q Science (General) A flavonoids-rich extract and seven flavonoids from the leaves and heartwoods of A. anisophyllus Miq. and A. lowii King were investigated for their inhibitory effects against acetylcholinesterase enzyme. The flavonoids were fully characterized spectroscopically as artocarpin (1), isobavachalcone (2), pyranocycloartobiloxanthone A (3), 5,7-dihydroxy-4'-methoxy-6-prenylflavanone (4), 5-hydroxy-7,8-(2,2-dimethylchromano)-4'-methoxy-flavanone (5) 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallylflavone (6) and 2',4'-dihydroxy-3,4-(2",2"-dimethylchromeno)-3'-prenyldihydrochalcone (7). Acetylcholinesterase inhibitory activity of the samples was determined using TLC plate with bioactivity staining based on the Ellman’s method. Pyranocycloartobiloxanthone A (3) exhibited an excellent inhibitory activity with detection limit at 7.81 µg/mL. Universiti Pendidikan Sultan Idris 2022-10-21 Article PeerReviewed application/pdf en http://eprints.utm.my/56137/1/SitiAwanisAbdullahSitiMariamAbdulLathiffShajarahtunnurJamil2022_AcetylcholinesteraseActivityofCrudeExtracts.pdf Jamil, Shajarahtunnur and Abdul Lathiff, Siti Mariam and Abdullah, Siti Awanis (2022) Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. Journal Of Science And Mathematics Letters, 10 (2). pp. 62-66. ISSN 2462-2052 https://ejournal.upsi.edu.my/index.php/JSML/article/view/7009 NA |
| spellingShingle | Q Science (General) Jamil, Shajarahtunnur Abdul Lathiff, Siti Mariam Abdullah, Siti Awanis Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. |
| title | Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. |
| title_full | Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. |
| title_fullStr | Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. |
| title_full_unstemmed | Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. |
| title_short | Acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq. And artocarpus lowii king. |
| title_sort | acetylcholinesterase activity of crude extracts and flavonoids from artocarpus anisophyllus miq and artocarpus lowii king |
| topic | Q Science (General) |
| url | http://eprints.utm.my/56137/1/SitiAwanisAbdullahSitiMariamAbdulLathiffShajarahtunnurJamil2022_AcetylcholinesteraseActivityofCrudeExtracts.pdf |
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