Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography
Linearity assessment as a required performance in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by laboratory chemist in assessing l...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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2008
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| Online Access: | http://eprints.utm.my/5669/2/MarsinSanagi20080604_Linearity_Assessment_According_IUPAC.pdf |
| _version_ | 1825909771044126720 |
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| author | Sanagi, Mohd. Marsin Nasir, Zalilah Lu, Susie Ling Wan Ibrahim, Wan Aini Abu Naim, Ahmedy |
| author_facet | Sanagi, Mohd. Marsin Nasir, Zalilah Lu, Susie Ling Wan Ibrahim, Wan Aini Abu Naim, Ahmedy |
| author_sort | Sanagi, Mohd. Marsin |
| collection | ePrints |
| description | Linearity assessment as a required performance in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by laboratory chemist in assessing linearity. Thus, this work proposes a simple method for linearity assessment in method validation by a regression analysis that covers experimental design, estimation of the parameters, outlier treatment, and evaluation of the assumptions according to IUPAC Guidelines. The suitability of this procedure was demonstrated by its application to an in-house validation for the determination of plasticizers in plastic food packaging by gas chromatography. |
| first_indexed | 2024-03-05T18:07:07Z |
| format | Article |
| id | utm.eprints-5669 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T18:07:07Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | utm.eprints-56692017-09-12T07:20:57Z http://eprints.utm.my/5669/ Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography Sanagi, Mohd. Marsin Nasir, Zalilah Lu, Susie Ling Wan Ibrahim, Wan Aini Abu Naim, Ahmedy QD Chemistry Linearity assessment as a required performance in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by laboratory chemist in assessing linearity. Thus, this work proposes a simple method for linearity assessment in method validation by a regression analysis that covers experimental design, estimation of the parameters, outlier treatment, and evaluation of the assumptions according to IUPAC Guidelines. The suitability of this procedure was demonstrated by its application to an in-house validation for the determination of plasticizers in plastic food packaging by gas chromatography. 2008 Article NonPeerReviewed application/pdf en http://eprints.utm.my/5669/2/MarsinSanagi20080604_Linearity_Assessment_According_IUPAC.pdf Sanagi, Mohd. Marsin and Nasir, Zalilah and Lu, Susie Ling and Wan Ibrahim, Wan Aini and Abu Naim, Ahmedy (2008) Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography. Analytica Chimica Acta . (Unpublished) |
| spellingShingle | QD Chemistry Sanagi, Mohd. Marsin Nasir, Zalilah Lu, Susie Ling Wan Ibrahim, Wan Aini Abu Naim, Ahmedy Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography |
| title | Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography |
| title_full | Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography |
| title_fullStr | Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography |
| title_full_unstemmed | Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography |
| title_short | Linearity assessment according to IUPAC guidelines for the determination of plasticizers in plasters food packaging by gas chromatography |
| title_sort | linearity assessment according to iupac guidelines for the determination of plasticizers in plasters food packaging by gas chromatography |
| topic | QD Chemistry |
| url | http://eprints.utm.my/5669/2/MarsinSanagi20080604_Linearity_Assessment_According_IUPAC.pdf |
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