COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae)
Abstract Phytochemicals and anti-inflammatory activity were investigated in the leaves of Pellacalyx saccardianus from the Rhizophoraceae family. The powdered leaves were extracted using methanol in a soxhlet extractor. Purification of the methanol extract yielded two new compounds, (3S)(6R)-3-(4′-h...
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| Format: | Article |
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Elsevier Ltd
2015
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| author | Abed, Salam Ahmed Mohd. Sirat, Hasnah M. Zulkifli, Razauden |
| author_facet | Abed, Salam Ahmed Mohd. Sirat, Hasnah M. Zulkifli, Razauden |
| author_sort | Abed, Salam Ahmed |
| collection | ePrints |
| description | Abstract Phytochemicals and anti-inflammatory activity were investigated in the leaves of Pellacalyx saccardianus from the Rhizophoraceae family. The powdered leaves were extracted using methanol in a soxhlet extractor. Purification of the methanol extract yielded two new compounds, (3S)(6R)-3-(4′-hydroxybenzyl)-6-(6″-hydroxyphenethyl)-2,2-dimethyl-piperidin-4-one and 1,2-O-(1-methylethylidene)fucoside, together with six known compounds, β-amyrin palmitate, squalene, 24-ethylcholesta-5,22,25-trien-3β-ol, 5R-hydroxy-1,7-bis(5-hydroxyphenyl)heptan-3-one, 1,7-bis(4-hydroxyphenyl)hept-4-en-3-one and methyl-l-fucoside. An anti-inflammatory assay using COX-2 revealed that β-amyrin palmitate possessed the highest inhibitory effect (96.8%) at the lowest concentration (0.01 μM), which was higher than that of the positive controls, resveratrol (90.2%, 0.01 μM) and indomethacin (79.20%, 100 μM). This is the first report on the isolation of phytochemicals from the leaves of P. saccardianus and their anti-inflammatory activity. |
| first_indexed | 2024-03-05T19:41:39Z |
| format | Article |
| id | utm.eprints-58181 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:41:39Z |
| publishDate | 2015 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | utm.eprints-581812021-08-18T00:06:52Z http://eprints.utm.my/58181/ COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) Abed, Salam Ahmed Mohd. Sirat, Hasnah M. Zulkifli, Razauden QD Chemistry Abstract Phytochemicals and anti-inflammatory activity were investigated in the leaves of Pellacalyx saccardianus from the Rhizophoraceae family. The powdered leaves were extracted using methanol in a soxhlet extractor. Purification of the methanol extract yielded two new compounds, (3S)(6R)-3-(4′-hydroxybenzyl)-6-(6″-hydroxyphenethyl)-2,2-dimethyl-piperidin-4-one and 1,2-O-(1-methylethylidene)fucoside, together with six known compounds, β-amyrin palmitate, squalene, 24-ethylcholesta-5,22,25-trien-3β-ol, 5R-hydroxy-1,7-bis(5-hydroxyphenyl)heptan-3-one, 1,7-bis(4-hydroxyphenyl)hept-4-en-3-one and methyl-l-fucoside. An anti-inflammatory assay using COX-2 revealed that β-amyrin palmitate possessed the highest inhibitory effect (96.8%) at the lowest concentration (0.01 μM), which was higher than that of the positive controls, resveratrol (90.2%, 0.01 μM) and indomethacin (79.20%, 100 μM). This is the first report on the isolation of phytochemicals from the leaves of P. saccardianus and their anti-inflammatory activity. Elsevier Ltd 2015 Article PeerReviewed Abed, Salam Ahmed and Mohd. Sirat, Hasnah and M. Zulkifli, Razauden (2015) COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae). Phytochemistry Letters, 13 . pp. 20-29. ISSN 1869-8433 http://dx.doi.org/10.1016/j.phytol.2015.05.001 |
| spellingShingle | QD Chemistry Abed, Salam Ahmed Mohd. Sirat, Hasnah M. Zulkifli, Razauden COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) |
| title | COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) |
| title_full | COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) |
| title_fullStr | COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) |
| title_full_unstemmed | COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) |
| title_short | COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) |
| title_sort | cox 2 inhibitors from the leaves of pellacalyx saccardianus scortech rhizophoraceae |
| topic | QD Chemistry |
| work_keys_str_mv | AT abedsalamahmed cox2inhibitorsfromtheleavesofpellacalyxsaccardianusscortechrhizophoraceae AT mohdsirathasnah cox2inhibitorsfromtheleavesofpellacalyxsaccardianusscortechrhizophoraceae AT mzulkiflirazauden cox2inhibitorsfromtheleavesofpellacalyxsaccardianusscortechrhizophoraceae |