Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques
Polyethersulfone (PES) based membranes are used for dialysis, but exposure to blood can result in numerous interactions between the blood elements and the membrane. Adsorption and transformation of plasma proteins, activation of blood cells, adherence of platelets and thrombosis reactions against PE...
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| Format: | Article |
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Materials Science and Engineering C09284931
2015
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| _version_ | 1796860569360269312 |
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| author | Irfan, Muhammad Ani, Idris |
| author_facet | Irfan, Muhammad Ani, Idris |
| author_sort | Irfan, Muhammad |
| collection | ePrints |
| description | Polyethersulfone (PES) based membranes are used for dialysis, but exposure to blood can result in numerous interactions between the blood elements and the membrane. Adsorption and transformation of plasma proteins, activation of blood cells, adherence of platelets and thrombosis reactions against PES membrane can invoke severe blood reactions causing the increase rate of mortality and morbidity of hemodialysis (HD) patients. In order to minimize blood immune response, different biomimetic, zwitterionic, non-ionic, anticoagulant molecules and hydrophilic brushes were immobilized or blended with PES polymers. These additives modified the nature of the membrane, enhanced their biocompatibility and also increased the uremic waste dialysis properties. In this review, current perspectives of the different additives which are used with PES are highlighted in relation with PES membrane-associated blood reactions. The additive's purpose, compatibility, preparation techniques, methods of addition to polymer and influence on the chemistry and performance of hemodialysis membranes are described. |
| first_indexed | 2024-03-05T19:43:20Z |
| format | Article |
| id | utm.eprints-58744 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:43:20Z |
| publishDate | 2015 |
| publisher | Materials Science and Engineering C09284931 |
| record_format | dspace |
| spelling | utm.eprints-587442022-04-10T04:08:09Z http://eprints.utm.my/58744/ Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques Irfan, Muhammad Ani, Idris QD Chemistry Polyethersulfone (PES) based membranes are used for dialysis, but exposure to blood can result in numerous interactions between the blood elements and the membrane. Adsorption and transformation of plasma proteins, activation of blood cells, adherence of platelets and thrombosis reactions against PES membrane can invoke severe blood reactions causing the increase rate of mortality and morbidity of hemodialysis (HD) patients. In order to minimize blood immune response, different biomimetic, zwitterionic, non-ionic, anticoagulant molecules and hydrophilic brushes were immobilized or blended with PES polymers. These additives modified the nature of the membrane, enhanced their biocompatibility and also increased the uremic waste dialysis properties. In this review, current perspectives of the different additives which are used with PES are highlighted in relation with PES membrane-associated blood reactions. The additive's purpose, compatibility, preparation techniques, methods of addition to polymer and influence on the chemistry and performance of hemodialysis membranes are described. Materials Science and Engineering C09284931 2015 Article PeerReviewed Irfan, Muhammad and Ani, Idris (2015) Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques. Materials Science and Engineering C, 56 . pp. 574-592. ISSN 9284-931 http://dx.doi.org/110.1016/j.msec.2015.06.035 DOI:10.1016/j.msec.2015.06.035 |
| spellingShingle | QD Chemistry Irfan, Muhammad Ani, Idris Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques |
| title | Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques |
| title_full | Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques |
| title_fullStr | Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques |
| title_full_unstemmed | Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques |
| title_short | Overview of PES biocompatible/hemodialysis membranes: PES-blood interactions and modification techniques |
| title_sort | overview of pes biocompatible hemodialysis membranes pes blood interactions and modification techniques |
| topic | QD Chemistry |
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