Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping
Single cell analysis has become the interest of a wide range of biological and biomedical engineering research. It could provide precise information of the individual cells which leads to important knowledge regarding human's diseases. Many attempts have been done to perform single cell analysi...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2015
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| Online Access: | http://eprints.utm.my/59395/1/AmeliaAhmadKhalili2014_NumericalSimulationofHydrodynamic.pdf |
| _version_ | 1796860702321803264 |
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| author | Khalili, A. A. Basri, M. A. M. Binslem, S. Ahmad, M. R. |
| author_facet | Khalili, A. A. Basri, M. A. M. Binslem, S. Ahmad, M. R. |
| author_sort | Khalili, A. A. |
| collection | ePrints |
| description | Single cell analysis has become the interest of a wide range of biological and biomedical engineering research. It could provide precise information of the individual cells which leads to important knowledge regarding human's diseases. Many attempts have been done to perform single cell analysis which require the isolation of individual cells before further manipulation could be carried out. Recently, microfluidic has been widely used for cell trapping and single cell analysis such as mechanical and electrical detection. Hydrodynamic trapping could be applied in the microfluidic device to trap a single cell thus providing platform for further cell characterization. This paper presents a finite element model for single cell trapping using hydrodynamic concept. The proposed microfluidic device consists of two parallel microchannels (main channel and trapping channel). Fluid's flow rates are optimized by performing microchannel geometrical size manipulation to isolate a 5 μm yeast cell. The analysis was carried out using finite element ABAQUS-FEA software. The optimized RhMain/RhTrap ratio was 3.5 and above for successful trapping. |
| first_indexed | 2024-03-05T19:45:15Z |
| format | Conference or Workshop Item |
| id | utm.eprints-59395 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T19:45:15Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | utm.eprints-593952021-08-11T08:09:21Z http://eprints.utm.my/59395/ Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping Khalili, A. A. Basri, M. A. M. Binslem, S. Ahmad, M. R. TK Electrical engineering. Electronics Nuclear engineering Single cell analysis has become the interest of a wide range of biological and biomedical engineering research. It could provide precise information of the individual cells which leads to important knowledge regarding human's diseases. Many attempts have been done to perform single cell analysis which require the isolation of individual cells before further manipulation could be carried out. Recently, microfluidic has been widely used for cell trapping and single cell analysis such as mechanical and electrical detection. Hydrodynamic trapping could be applied in the microfluidic device to trap a single cell thus providing platform for further cell characterization. This paper presents a finite element model for single cell trapping using hydrodynamic concept. The proposed microfluidic device consists of two parallel microchannels (main channel and trapping channel). Fluid's flow rates are optimized by performing microchannel geometrical size manipulation to isolate a 5 μm yeast cell. The analysis was carried out using finite element ABAQUS-FEA software. The optimized RhMain/RhTrap ratio was 3.5 and above for successful trapping. 2015 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.utm.my/59395/1/AmeliaAhmadKhalili2014_NumericalSimulationofHydrodynamic.pdf Khalili, A. A. and Basri, M. A. M. and Binslem, S. and Ahmad, M. R. (2015) Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping. In: 3rd IEEE Conference on Biomedical Engineering and Sciences, IECBES 2014, 8-10 Dec 2014, Kuala Lumpur, Malaysia. http://www.dx.doi.org/10.1109/IECBES.2014.7047546 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering Khalili, A. A. Basri, M. A. M. Binslem, S. Ahmad, M. R. Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping |
| title | Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping |
| title_full | Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping |
| title_fullStr | Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping |
| title_full_unstemmed | Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping |
| title_short | Numerical simulation of hydrodynamic-based microfluidic device for single cell trapping |
| title_sort | numerical simulation of hydrodynamic based microfluidic device for single cell trapping |
| topic | TK Electrical engineering. Electronics Nuclear engineering |
| url | http://eprints.utm.my/59395/1/AmeliaAhmadKhalili2014_NumericalSimulationofHydrodynamic.pdf |
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