Two-stage robust estimators for product concentration in a penicillin fermentation
Two strategies are proposed for inferential estimations of penicillin concentration in a fed-batch fermentation process. The first scheme employs a partial least squares (PLS)-based estimator to directly estimate the intended product concentration. The second introduces a two-step estimation where b...
| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2004
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| Subjects: | |
| Online Access: | http://eprints.utm.my/5944/1/A.W.Chow2004_TwoStageRobustEstimatorsForProduct.pdf |
| Summary: | Two strategies are proposed for inferential estimations of penicillin concentration in a fed-batch fermentation process. The first scheme employs a partial least squares (PLS)-based estimator to directly estimate the intended product concentration. The second introduces a two-step estimation where biomass concentration is first estimated and used as the input to the final estimator along with other process variables. The results confirmed the strength of the two-stage approach. To further extend the capability of the estimation scheme, a wavelet-based filter is added to the estimation model. The improved performance obtained proved the efficacy of the wavelet filter. |
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