Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent
A series of chalcones, a flavone and one flavanone were synthesized and elucidated structurally by IR and 1H NMR spectroscopies. The synthetic compounds were then screened for acetylcholinesterase inhibitory activity using thin layer chromatography (TLC) and microplate assays. In the TLC assay, only...
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| Format: | Article |
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Penerbit UTM Press
2014
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| _version_ | 1796861331928776704 |
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| author | Ibrahim, Saleh Nazifi Amad, Farediah |
| author_facet | Ibrahim, Saleh Nazifi Amad, Farediah |
| author_sort | Ibrahim, Saleh Nazifi |
| collection | ePrints |
| description | A series of chalcones, a flavone and one flavanone were synthesized and elucidated structurally by IR and 1H NMR spectroscopies. The synthetic compounds were then screened for acetylcholinesterase inhibitory activity using thin layer chromatography (TLC) and microplate assays. In the TLC assay, only 2′-hydroxy-4-methoxychalcone and 2′-hydroxy-4′-O-prenyl-2,6-dichlorochalcone were found to show moderate and weak activity respectively against acetylcholinesterase (AchE) at 0.1 mM concentration compared to the control galanthamine. 4′-Hydroxy-2,6-dichlorochalcone, 2′-hydroxy-4-nitrochalcone, 2′-hydroxy-4-(dimethyl)aminochalcone and 2′-hydroxy-4-methoxychalcone showed moderate AchE inhibitory activity with percentage inhibition of 54.24, 46.14 and 49.32 % respectively in the microplate assay. |
| first_indexed | 2024-03-05T19:54:43Z |
| format | Article |
| id | utm.eprints-62765 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:54:43Z |
| publishDate | 2014 |
| publisher | Penerbit UTM Press |
| record_format | dspace |
| spelling | utm.eprints-627652017-11-01T04:17:08Z http://eprints.utm.my/62765/ Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent Ibrahim, Saleh Nazifi Amad, Farediah Q Science A series of chalcones, a flavone and one flavanone were synthesized and elucidated structurally by IR and 1H NMR spectroscopies. The synthetic compounds were then screened for acetylcholinesterase inhibitory activity using thin layer chromatography (TLC) and microplate assays. In the TLC assay, only 2′-hydroxy-4-methoxychalcone and 2′-hydroxy-4′-O-prenyl-2,6-dichlorochalcone were found to show moderate and weak activity respectively against acetylcholinesterase (AchE) at 0.1 mM concentration compared to the control galanthamine. 4′-Hydroxy-2,6-dichlorochalcone, 2′-hydroxy-4-nitrochalcone, 2′-hydroxy-4-(dimethyl)aminochalcone and 2′-hydroxy-4-methoxychalcone showed moderate AchE inhibitory activity with percentage inhibition of 54.24, 46.14 and 49.32 % respectively in the microplate assay. Penerbit UTM Press 2014 Article PeerReviewed Ibrahim, Saleh Nazifi and Amad, Farediah (2014) Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent. Jurnal Teknologi (Sciences and Engineering), 69 (1). pp. 97-102. ISSN 2180-3722 http://dx.doi.org/10.11113/jt.v69.2588 DOI:10.11113/jt.v69.2588 |
| spellingShingle | Q Science Ibrahim, Saleh Nazifi Amad, Farediah Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent |
| title | Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent |
| title_full | Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent |
| title_fullStr | Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent |
| title_full_unstemmed | Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent |
| title_short | Synthesis and biological evaluation of flavonoids as antiacetyl-cholinesterase agent |
| title_sort | synthesis and biological evaluation of flavonoids as antiacetyl cholinesterase agent |
| topic | Q Science |
| work_keys_str_mv | AT ibrahimsalehnazifi synthesisandbiologicalevaluationofflavonoidsasantiacetylcholinesteraseagent AT amadfarediah synthesisandbiologicalevaluationofflavonoidsasantiacetylcholinesteraseagent |