Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement
In this research, a finite element study on a nanoneedle-microfluidic system for single cell temperature measurement is presented. The nanoneedle design and electrical and mechanical characterization are analyzed, in which tungsten is used as the sensing material. A rectangular shaped sensor with a...
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| Format: | Article |
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MDPI AG
2016
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| author | Salma, Abdullah Binsilm Rad, Maryam Alsadat Ahmad, Mohd. Ridzuan |
| author_facet | Salma, Abdullah Binsilm Rad, Maryam Alsadat Ahmad, Mohd. Ridzuan |
| author_sort | Salma, Abdullah Binsilm |
| collection | ePrints |
| description | In this research, a finite element study on a nanoneedle-microfluidic system for single cell temperature measurement is presented. The nanoneedle design and electrical and mechanical characterization are analyzed, in which tungsten is used as the sensing material. A rectangular shaped sensor with a gap of 10.8 µm showed to give the same current density distribution within the nanoneedle, and a 90 nm2 cross-sectional area showed to cause minimum damage to the cell. Furthermore, the current showed to have a positive temperature coefficient of resistance (TCR) with an increase in the temperature, and the nanoneedle showed to be able to resist ramp force up to 22.5 μN before failure. Electrical measurement on yeast cell showed that the nanoneedle was independent of the cell conductivity. The nanoneedle proved to be able to measure temperature with a current difference of 50 nA and a resolution of 0.02 °C in 10 ms. A Y-shaped microchannel was proposed and the microchannel cross-sectional area was optimized to be 63 μm2 and a flow rate of 24.6 pL/min allowed successful cell penetration causing minimal damage to the cell. |
| first_indexed | 2024-03-05T19:58:49Z |
| format | Article |
| id | utm.eprints-68249 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T19:58:49Z |
| publishDate | 2016 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | utm.eprints-682492017-11-30T02:15:30Z http://eprints.utm.my/68249/ Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement Salma, Abdullah Binsilm Rad, Maryam Alsadat Ahmad, Mohd. Ridzuan TK Electrical engineering. Electronics Nuclear engineering In this research, a finite element study on a nanoneedle-microfluidic system for single cell temperature measurement is presented. The nanoneedle design and electrical and mechanical characterization are analyzed, in which tungsten is used as the sensing material. A rectangular shaped sensor with a gap of 10.8 µm showed to give the same current density distribution within the nanoneedle, and a 90 nm2 cross-sectional area showed to cause minimum damage to the cell. Furthermore, the current showed to have a positive temperature coefficient of resistance (TCR) with an increase in the temperature, and the nanoneedle showed to be able to resist ramp force up to 22.5 μN before failure. Electrical measurement on yeast cell showed that the nanoneedle was independent of the cell conductivity. The nanoneedle proved to be able to measure temperature with a current difference of 50 nA and a resolution of 0.02 °C in 10 ms. A Y-shaped microchannel was proposed and the microchannel cross-sectional area was optimized to be 63 μm2 and a flow rate of 24.6 pL/min allowed successful cell penetration causing minimal damage to the cell. MDPI AG 2016-01-12 Article PeerReviewed Salma, Abdullah Binsilm and Rad, Maryam Alsadat and Ahmad, Mohd. Ridzuan (2016) Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement. Applied Sciences, 6 (12). p. 339. ISSN 2076-3417 http://www.mdpi.com/2076-3417/6/12/339 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering Salma, Abdullah Binsilm Rad, Maryam Alsadat Ahmad, Mohd. Ridzuan Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement |
| title | Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement |
| title_full | Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement |
| title_fullStr | Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement |
| title_full_unstemmed | Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement |
| title_short | Modeling of integrated nanoneedle-microfluidic system for single cell temperature measurement |
| title_sort | modeling of integrated nanoneedle microfluidic system for single cell temperature measurement |
| topic | TK Electrical engineering. Electronics Nuclear engineering |
| work_keys_str_mv | AT salmaabdullahbinsilm modelingofintegratednanoneedlemicrofluidicsystemforsinglecelltemperaturemeasurement AT radmaryamalsadat modelingofintegratednanoneedlemicrofluidicsystemforsinglecelltemperaturemeasurement AT ahmadmohdridzuan modelingofintegratednanoneedlemicrofluidicsystemforsinglecelltemperaturemeasurement |