Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release
This paper reports for the first time the reinforcement of kappa-carrageenan (ĸCRG) with clay of halloysite nanotubes (HNT) as potential biomedical materials. The bionanocomposite films (ĸCRG/HNT) were successfully prepared having optimum tensile properties at 3 wt% of HNT. Morphological and surface...
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| Format: | Article |
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Inst Materials Physics
2016
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| author | Wahab, I. F. Abd Razak, S. I. |
| author_facet | Wahab, I. F. Abd Razak, S. I. |
| author_sort | Wahab, I. F. |
| collection | ePrints |
| description | This paper reports for the first time the reinforcement of kappa-carrageenan (ĸCRG) with clay of halloysite nanotubes (HNT) as potential biomedical materials. The bionanocomposite films (ĸCRG/HNT) were successfully prepared having optimum tensile properties at 3 wt% of HNT. Morphological and surface analysis of the nanocomposite revealed excellent film formation and increased in surface roughness. Immersion of the film in simulated body fluid for 7 days resulted in the growth of hydroxyl apatite particles with Ca/P ratio of 1.68. This is a good indication of bioactivity for possible template in bone tissue engineering. Swelling and methylene blue release experiments indicated possible drug delivery applications due to the stability of the ĸCRG matrix up to more than 20 days and delayed release of the model drug, respectively. This bioresource nanocomposite film has potential as a suitable biomedical material that requires mechanical integrity, bioactivity and drug releasing. |
| first_indexed | 2024-03-05T20:03:38Z |
| format | Article |
| id | utm.eprints-72337 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:03:38Z |
| publishDate | 2016 |
| publisher | Inst Materials Physics |
| record_format | dspace |
| spelling | utm.eprints-723372017-11-20T08:23:46Z http://eprints.utm.my/72337/ Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release Wahab, I. F. Abd Razak, S. I. R Medicine (General) This paper reports for the first time the reinforcement of kappa-carrageenan (ĸCRG) with clay of halloysite nanotubes (HNT) as potential biomedical materials. The bionanocomposite films (ĸCRG/HNT) were successfully prepared having optimum tensile properties at 3 wt% of HNT. Morphological and surface analysis of the nanocomposite revealed excellent film formation and increased in surface roughness. Immersion of the film in simulated body fluid for 7 days resulted in the growth of hydroxyl apatite particles with Ca/P ratio of 1.68. This is a good indication of bioactivity for possible template in bone tissue engineering. Swelling and methylene blue release experiments indicated possible drug delivery applications due to the stability of the ĸCRG matrix up to more than 20 days and delayed release of the model drug, respectively. This bioresource nanocomposite film has potential as a suitable biomedical material that requires mechanical integrity, bioactivity and drug releasing. Inst Materials Physics 2016 Article PeerReviewed Wahab, I. F. and Abd Razak, S. I. (2016) Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release. Digest Journal of Nanomaterials and Biostructures, 11 (3). pp. 963-972. ISSN 1842-3582 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84987762579&partnerID=40&md5=921e33d7ee7916808eced895ffa22986 |
| spellingShingle | R Medicine (General) Wahab, I. F. Abd Razak, S. I. Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release |
| title | Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release |
| title_full | Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release |
| title_fullStr | Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release |
| title_full_unstemmed | Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release |
| title_short | Bionanocomposite film of kappa-carrageenan / nanotube clay: growth of hydroxyl apatite and model drug release |
| title_sort | bionanocomposite film of kappa carrageenan nanotube clay growth of hydroxyl apatite and model drug release |
| topic | R Medicine (General) |
| work_keys_str_mv | AT wahabif bionanocompositefilmofkappacarrageenannanotubeclaygrowthofhydroxylapatiteandmodeldrugrelease AT abdrazaksi bionanocompositefilmofkappacarrageenannanotubeclaygrowthofhydroxylapatiteandmodeldrugrelease |