Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae)
Cholinesterase inhibition activities were screened on crude extracts and isolated compounds of the heartwood of Artocarpus fulvicortex. Phytochemical studies on the heartwood of A. fulvicortex have resulted in the isolation of one flavonoid, one stilbenoid and two triterpenes. Their structures were...
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Penerbit UTM Press
2016
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| Online Access: | http://eprints.utm.my/72431/1/MasuriKamaKamaruddinShah2016_CholinesteraseInhibitorsfromHeartwoodofArtocarpus.pdf |
| _version_ | 1796861932267896832 |
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| author | Shah, M. K. K. Sirat, H. M. Jamil, S. |
| author_facet | Shah, M. K. K. Sirat, H. M. Jamil, S. |
| author_sort | Shah, M. K. K. |
| collection | ePrints |
| description | Cholinesterase inhibition activities were screened on crude extracts and isolated compounds of the heartwood of Artocarpus fulvicortex. Phytochemical studies on the heartwood of A. fulvicortex have resulted in the isolation of one flavonoid, one stilbenoid and two triterpenes. Their structures were determined by spectroscopic analysis as catechin (1), oxyresveratrol (2), lupeol-3-acetate (3) and friedelin (4). All isolates were evaluated for the first time for anti-cholinesterase activity. Inhibition of acetylcholinesterase (AChE), tested by Ellman’s method and modified TLC bioautographic assay showed catechin (1) and oxyresvetratrol (2) were active agents with detection limit of 2 mM. The microplate assay was carried out using butyrylcholinesterase (BChe) to further confirmed that catechin (1) and oxyresvetratrol (2) displayed positive cholinesterase activity with IC50 values 50.0 mM and 6.25 mM respectively in dose dependent manner. |
| first_indexed | 2024-03-05T20:03:54Z |
| format | Article |
| id | utm.eprints-72431 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T20:03:54Z |
| publishDate | 2016 |
| publisher | Penerbit UTM Press |
| record_format | dspace |
| spelling | utm.eprints-724312017-11-22T12:07:40Z http://eprints.utm.my/72431/ Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae) Shah, M. K. K. Sirat, H. M. Jamil, S. QD Chemistry Cholinesterase inhibition activities were screened on crude extracts and isolated compounds of the heartwood of Artocarpus fulvicortex. Phytochemical studies on the heartwood of A. fulvicortex have resulted in the isolation of one flavonoid, one stilbenoid and two triterpenes. Their structures were determined by spectroscopic analysis as catechin (1), oxyresveratrol (2), lupeol-3-acetate (3) and friedelin (4). All isolates were evaluated for the first time for anti-cholinesterase activity. Inhibition of acetylcholinesterase (AChE), tested by Ellman’s method and modified TLC bioautographic assay showed catechin (1) and oxyresvetratrol (2) were active agents with detection limit of 2 mM. The microplate assay was carried out using butyrylcholinesterase (BChe) to further confirmed that catechin (1) and oxyresvetratrol (2) displayed positive cholinesterase activity with IC50 values 50.0 mM and 6.25 mM respectively in dose dependent manner. Penerbit UTM Press 2016 Article PeerReviewed application/pdf en http://eprints.utm.my/72431/1/MasuriKamaKamaruddinShah2016_CholinesteraseInhibitorsfromHeartwoodofArtocarpus.pdf Shah, M. K. K. and Sirat, H. M. and Jamil, S. (2016) Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae). Jurnal Teknologi, 78 (6). pp. 185-189. ISSN 0127-9696 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971384333&doi=10.11113%2fjt.v78.4400&partnerID=40&md5=6befa9953b9d9ff6b1e180491cf8dbb5 |
| spellingShingle | QD Chemistry Shah, M. K. K. Sirat, H. M. Jamil, S. Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae) |
| title | Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae) |
| title_full | Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae) |
| title_fullStr | Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae) |
| title_full_unstemmed | Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae) |
| title_short | Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae) |
| title_sort | cholinesterase inhibitors from heartwood of artocarpus fulvicortex f m jarret moraceae |
| topic | QD Chemistry |
| url | http://eprints.utm.my/72431/1/MasuriKamaKamaruddinShah2016_CholinesteraseInhibitorsfromHeartwoodofArtocarpus.pdf |
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