Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5-hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Ca...
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| Format: | Article |
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Elsevier Ltd
2016
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| _version_ | 1796861941570863104 |
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| author | Aminudin, N. I. Ahmad, F. Taher, M. Zulkifli, R. M. |
| author_facet | Aminudin, N. I. Ahmad, F. Taher, M. Zulkifli, R. M. |
| author_sort | Aminudin, N. I. |
| collection | ePrints |
| description | Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5-hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The structures of the compounds were determined by spectroscopic means. The compounds were tested for their cytotoxic activity towards MCF-7 and A-549 cell lines and α-glucosidase enzymatic inhibitory activity. Compound (1) displayed cytotoxic activity against A-549 cell lines with IC50 87.71 μg/mL and showed inhibition towards α-glucosidase enzymatic activity with IC50 93.25 μM. This is the first report on the isolation of phytochemicals from the barks and leaves of C. incrassatum and their bioactivities. |
| first_indexed | 2024-03-05T20:04:02Z |
| format | Article |
| id | utm.eprints-72482 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:04:02Z |
| publishDate | 2016 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | utm.eprints-724822017-11-26T03:37:04Z http://eprints.utm.my/72482/ Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities Aminudin, N. I. Ahmad, F. Taher, M. Zulkifli, R. M. QD Chemistry Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5-hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The structures of the compounds were determined by spectroscopic means. The compounds were tested for their cytotoxic activity towards MCF-7 and A-549 cell lines and α-glucosidase enzymatic inhibitory activity. Compound (1) displayed cytotoxic activity against A-549 cell lines with IC50 87.71 μg/mL and showed inhibition towards α-glucosidase enzymatic activity with IC50 93.25 μM. This is the first report on the isolation of phytochemicals from the barks and leaves of C. incrassatum and their bioactivities. Elsevier Ltd 2016 Article PeerReviewed Aminudin, N. I. and Ahmad, F. and Taher, M. and Zulkifli, R. M. (2016) Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities. Phytochemistry Letters, 16 . pp. 287-293. ISSN 1874-3900 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84977620941&doi=10.1016%2fj.phytol.2016.05.008&partnerID=40&md5=44356757370cb55ac5c84d785302817f |
| spellingShingle | QD Chemistry Aminudin, N. I. Ahmad, F. Taher, M. Zulkifli, R. M. Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities |
| title | Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities |
| title_full | Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities |
| title_fullStr | Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities |
| title_full_unstemmed | Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities |
| title_short | Incrassamarin A–D: four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities |
| title_sort | incrassamarin a d four new 4 substituted coumarins from calophyllum incrassatum and their biological activities |
| topic | QD Chemistry |
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