Beyond classical meta-analysis: Can inadequately reported studies be included?
Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to inclu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004
|
| Online Access: | http://eprints.utm.my/7379/1/Nik_Rumzi_Nik_Idris_2004_Beyond_Classical_Meta-analysis.pdf |
| _version_ | 1796854210572058624 |
|---|---|
| author | Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter |
| author_facet | Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter |
| author_sort | Robertson, Chris |
| collection | ePrints |
| description | Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required. |
| first_indexed | 2024-03-05T18:11:00Z |
| format | Article |
| id | utm.eprints-7379 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T18:11:00Z |
| publishDate | 2004 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | utm.eprints-73792010-06-01T15:51:39Z http://eprints.utm.my/7379/ Beyond classical meta-analysis: Can inadequately reported studies be included? Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required. Elsevier 2004-11-01 Article PeerReviewed application/pdf en http://eprints.utm.my/7379/1/Nik_Rumzi_Nik_Idris_2004_Beyond_Classical_Meta-analysis.pdf Robertson, Chris and Nik Idris, Nik Ruzni and Boyle, Peter (2004) Beyond classical meta-analysis: Can inadequately reported studies be included? Drug Discovery Today, 9 (21). pp. 924-931. ISSN 1359-6446 http://dx.doi.org/10.1016/S1359-6446(04)03274-X 10.1016/S1359-6446(04)03274-X |
| spellingShingle | Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter Beyond classical meta-analysis: Can inadequately reported studies be included? |
| title | Beyond classical meta-analysis: Can inadequately reported studies be included? |
| title_full | Beyond classical meta-analysis: Can inadequately reported studies be included? |
| title_fullStr | Beyond classical meta-analysis: Can inadequately reported studies be included? |
| title_full_unstemmed | Beyond classical meta-analysis: Can inadequately reported studies be included? |
| title_short | Beyond classical meta-analysis: Can inadequately reported studies be included? |
| title_sort | beyond classical meta analysis can inadequately reported studies be included |
| url | http://eprints.utm.my/7379/1/Nik_Rumzi_Nik_Idris_2004_Beyond_Classical_Meta-analysis.pdf |
| work_keys_str_mv | AT robertsonchris beyondclassicalmetaanalysiscaninadequatelyreportedstudiesbeincluded AT nikidrisnikruzni beyondclassicalmetaanalysiscaninadequatelyreportedstudiesbeincluded AT boylepeter beyondclassicalmetaanalysiscaninadequatelyreportedstudiesbeincluded |