Metabolomics, lipidomics and pharmacometabolomics of human hypertension
Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular...
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| Format: | Book Section |
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Springer New York LLC
2017
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| author | Au, A. Cheng, K. K. Wei, L. K. |
| author_facet | Au, A. Cheng, K. K. Wei, L. K. |
| author_sort | Au, A. |
| collection | ePrints |
| description | Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular mechanism of hypertension. Although there have been limited metabolomic, lipidomic and pharmacometabolomic studies investigating this disease to date, metabolomic studies on hypertension have provided greater insights into the identification of disease-specific biomarkers, predicting treatment outcome and monitor drug safety and efficacy. Therefore, we discuss recent updates on the applications of metabolomics technology in human hypertension with a focus on metabolic biomarker discovery. |
| first_indexed | 2024-03-05T20:08:59Z |
| format | Book Section |
| id | utm.eprints-74819 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:08:59Z |
| publishDate | 2017 |
| publisher | Springer New York LLC |
| record_format | dspace |
| spelling | utm.eprints-748192017-11-28T08:38:31Z http://eprints.utm.my/74819/ Metabolomics, lipidomics and pharmacometabolomics of human hypertension Au, A. Cheng, K. K. Wei, L. K. TP Chemical technology Hypertension is a common but complex human disease, which can lead to a heart attack, stroke, kidney disease or other complications. Since the pathogenesis of hypertension is heterogeneous and multifactorial, it is crucial to establish a comprehensive metabolomic approach to elucidate the molecular mechanism of hypertension. Although there have been limited metabolomic, lipidomic and pharmacometabolomic studies investigating this disease to date, metabolomic studies on hypertension have provided greater insights into the identification of disease-specific biomarkers, predicting treatment outcome and monitor drug safety and efficacy. Therefore, we discuss recent updates on the applications of metabolomics technology in human hypertension with a focus on metabolic biomarker discovery. Springer New York LLC 2017 Book Section PeerReviewed Au, A. and Cheng, K. K. and Wei, L. K. (2017) Metabolomics, lipidomics and pharmacometabolomics of human hypertension. In: Advances in Experimental Medicine and Biology. Springer New York LLC, pp. 599-613. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019191365&doi=10.1007%2f5584_2016_79&partnerID=40&md5=e2e555410fda3a18e2f93ed2bba2d60f |
| spellingShingle | TP Chemical technology Au, A. Cheng, K. K. Wei, L. K. Metabolomics, lipidomics and pharmacometabolomics of human hypertension |
| title | Metabolomics, lipidomics and pharmacometabolomics of human hypertension |
| title_full | Metabolomics, lipidomics and pharmacometabolomics of human hypertension |
| title_fullStr | Metabolomics, lipidomics and pharmacometabolomics of human hypertension |
| title_full_unstemmed | Metabolomics, lipidomics and pharmacometabolomics of human hypertension |
| title_short | Metabolomics, lipidomics and pharmacometabolomics of human hypertension |
| title_sort | metabolomics lipidomics and pharmacometabolomics of human hypertension |
| topic | TP Chemical technology |
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