PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane
In this study, biodegradable and biocompatible polylactic acid (PLA) and poly(3-hyroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend polymer solutions were electrospun using electrospinning technique. Polymer blend ratio and electrospinning voltage were varied and optimized. The fabricated electrospun...
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| Format: | Article |
| Language: | English |
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Cogent OA
2017
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| Online Access: | http://eprints.utm.my/75932/1/NazninSultana_PLAPHBVElectrospunMembraneFabricationCoating.pdf |
| _version_ | 1796862432582303744 |
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| author | Chang, H. C. Sultana, N. |
| author_facet | Chang, H. C. Sultana, N. |
| author_sort | Chang, H. C. |
| collection | ePrints |
| description | In this study, biodegradable and biocompatible polylactic acid (PLA) and poly(3-hyroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend polymer solutions were electrospun using electrospinning technique. Polymer blend ratio and electrospinning voltage were varied and optimized. The fabricated electrospun PLA/PHBV membranes were dipped into poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) solution to produce conductive PEDOT:PSS coated membranes. The coated and uncoated membranes were investigated using scanning electron microscopy (SEM), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and water uptake measurement. PEDOT:PSS coated membranes were then loaded with drug (tetracycline hydrochloride) and their antibacterial activity was investigated. Beadless PLA/PHBV membranes were successfully fabricated. The fabricated PLA/PHBV membranes were rendered conductive by dipping them into poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) solution. Drug loaded membranes showed antibacterial properties which was confirmed by zone inhibition method. |
| first_indexed | 2024-03-05T20:11:32Z |
| format | Article |
| id | utm.eprints-75932 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T20:11:32Z |
| publishDate | 2017 |
| publisher | Cogent OA |
| record_format | dspace |
| spelling | utm.eprints-759322018-05-30T04:11:12Z http://eprints.utm.my/75932/ PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane Chang, H. C. Sultana, N. QH301 Biology In this study, biodegradable and biocompatible polylactic acid (PLA) and poly(3-hyroxybutyrate-co-3-hydroxyvalerate) (PHBV) blend polymer solutions were electrospun using electrospinning technique. Polymer blend ratio and electrospinning voltage were varied and optimized. The fabricated electrospun PLA/PHBV membranes were dipped into poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) solution to produce conductive PEDOT:PSS coated membranes. The coated and uncoated membranes were investigated using scanning electron microscopy (SEM), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and water uptake measurement. PEDOT:PSS coated membranes were then loaded with drug (tetracycline hydrochloride) and their antibacterial activity was investigated. Beadless PLA/PHBV membranes were successfully fabricated. The fabricated PLA/PHBV membranes were rendered conductive by dipping them into poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) solution. Drug loaded membranes showed antibacterial properties which was confirmed by zone inhibition method. Cogent OA 2017 Article PeerReviewed application/pdf en http://eprints.utm.my/75932/1/NazninSultana_PLAPHBVElectrospunMembraneFabricationCoating.pdf Chang, H. C. and Sultana, N. (2017) PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane. Cogent Engineering, 4 (1). ISSN 2331-1916 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018303063&doi=10.1080%2f23311916.2017.1322479&partnerID=40&md5=dcd4a3bdb0a352bb36c815b16e0dad38 |
| spellingShingle | QH301 Biology Chang, H. C. Sultana, N. PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane |
| title | PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane |
| title_full | PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane |
| title_fullStr | PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane |
| title_full_unstemmed | PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane |
| title_short | PLA/PHBV electrospun membrane: Fabrication, coating with conductive PEDOT:PSS and antibacterial activity of drug loaded membrane |
| title_sort | pla phbv electrospun membrane fabrication coating with conductive pedot pss and antibacterial activity of drug loaded membrane |
| topic | QH301 Biology |
| url | http://eprints.utm.my/75932/1/NazninSultana_PLAPHBVElectrospunMembraneFabricationCoating.pdf |
| work_keys_str_mv | AT changhc plaphbvelectrospunmembranefabricationcoatingwithconductivepedotpssandantibacterialactivityofdrugloadedmembrane AT sultanan plaphbvelectrospunmembranefabricationcoatingwithconductivepedotpssandantibacterialactivityofdrugloadedmembrane |