Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes
In this study, poly (1,8-octanediol citrate) (POC) was used to modify polyethersulfone (PES)-based membrane to enhance its hemocompatibility. Different compositions of POC (0–3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent....
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John Wiley and Sons Inc.
2017
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| author | Zailani, M. Z. Ismail, A. F. Sheikh Abdul Kadir, S. H. Othman, M. H. D. Goh, P. S. Hasbullah, H. Abdullah, M. S. Ng, B. C. Kamal, F. |
| author_facet | Zailani, M. Z. Ismail, A. F. Sheikh Abdul Kadir, S. H. Othman, M. H. D. Goh, P. S. Hasbullah, H. Abdullah, M. S. Ng, B. C. Kamal, F. |
| author_sort | Zailani, M. Z. |
| collection | ePrints |
| description | In this study, poly (1,8-octanediol citrate) (POC) was used to modify polyethersulfone (PES)-based membrane to enhance its hemocompatibility. Different compositions of POC (0–3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection. The hemocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), and thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+ absorption on membrane. Results showed that by increasing POC concentration, FBG adsorption was reduced, less platelets adhesion, prolonged APTT and PT, lower TAT, C5a and C3a activation and absorb more Ca2+ ion. These results indicated that modification of PES with POC has rendered improved hemocompatibility properties for potential application in the field of blood purification, especially in hemodialysis. |
| first_indexed | 2024-03-05T20:12:39Z |
| format | Article |
| id | utm.eprints-76435 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:12:39Z |
| publishDate | 2017 |
| publisher | John Wiley and Sons Inc. |
| record_format | dspace |
| spelling | utm.eprints-764352018-04-30T13:23:54Z http://eprints.utm.my/76435/ Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes Zailani, M. Z. Ismail, A. F. Sheikh Abdul Kadir, S. H. Othman, M. H. D. Goh, P. S. Hasbullah, H. Abdullah, M. S. Ng, B. C. Kamal, F. QH301 Biology In this study, poly (1,8-octanediol citrate) (POC) was used to modify polyethersulfone (PES)-based membrane to enhance its hemocompatibility. Different compositions of POC (0–3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection. The hemocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), and thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+ absorption on membrane. Results showed that by increasing POC concentration, FBG adsorption was reduced, less platelets adhesion, prolonged APTT and PT, lower TAT, C5a and C3a activation and absorb more Ca2+ ion. These results indicated that modification of PES with POC has rendered improved hemocompatibility properties for potential application in the field of blood purification, especially in hemodialysis. John Wiley and Sons Inc. 2017 Article PeerReviewed Zailani, M. Z. and Ismail, A. F. and Sheikh Abdul Kadir, S. H. and Othman, M. H. D. and Goh, P. S. and Hasbullah, H. and Abdullah, M. S. and Ng, B. C. and Kamal, F. (2017) Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes. Journal of Biomedical Materials Research - Part A, 105 (5). pp. 1510-1520. ISSN 1549-3296 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016240134&doi=10.1002%2fjbm.a.35986&partnerID=40&md5=0ce620b504c881c3aefab058c30d71ff DOI:10.1002/jbm.a.35986 |
| spellingShingle | QH301 Biology Zailani, M. Z. Ismail, A. F. Sheikh Abdul Kadir, S. H. Othman, M. H. D. Goh, P. S. Hasbullah, H. Abdullah, M. S. Ng, B. C. Kamal, F. Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes |
| title | Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes |
| title_full | Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes |
| title_fullStr | Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes |
| title_full_unstemmed | Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes |
| title_short | Hemocompatibility evaluation of poly(1,8-octanediol citrate) blend polyethersulfone membranes |
| title_sort | hemocompatibility evaluation of poly 1 8 octanediol citrate blend polyethersulfone membranes |
| topic | QH301 Biology |
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