Optimization of cordycepin extraction from cordyceps militaris fermentation broth
Cordyceps is one of the components of traditional Chinese medicine. This mushroom becomes worldwide famous due to its significant therapeutic effects on various diseases. Nucleoside like cordycepin, a major bioactive compound from Cordyceps militaris, is commonly known as promising anticancer and an...
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| Format: | Article |
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Scientific Publishers
2017
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| _version_ | 1796862526372184064 |
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| author | Soltani, M. Abd Malek, R. Ware, I. Ramli, S. Elsayed, E. A. Aziz, R. El-Enshasy, H. A. |
| author_facet | Soltani, M. Abd Malek, R. Ware, I. Ramli, S. Elsayed, E. A. Aziz, R. El-Enshasy, H. A. |
| author_sort | Soltani, M. |
| collection | ePrints |
| description | Cordyceps is one of the components of traditional Chinese medicine. This mushroom becomes worldwide famous due to its significant therapeutic effects on various diseases. Nucleoside like cordycepin, a major bioactive compound from Cordyceps militaris, is commonly known as promising anticancer and antitumor compound. The aim of study is to determine an optimal mixture ratio of solvent-solvent-based extraction method, which is used for extraction of cordycepin, from cultivated Cordyceps militaris DSMZ 23612 fermentation broth. Hence, the optimization process was performed using statistical (RSM) design leaded an optimal cordycepin extraction using solvent mixture including hot water (23%), ethanol (30%), methanol (25%) and ethyl acetate (22%). In addition, the final extracted cordycepin (786.94 mgL-1 of 81% purity) was achieved through extraction parameters as sample: solvent ratio (v/v), extraction temperature, extraction time and frequency at (1:10), 35 °C, 90 min and 1 cycle, respectively. The experimental values obtained were fit with those predicted, thus indicate the suitability of RSM and method for optimization of cordycepin extraction. |
| first_indexed | 2024-03-05T20:12:57Z |
| format | Article |
| id | utm.eprints-76545 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:12:57Z |
| publishDate | 2017 |
| publisher | Scientific Publishers |
| record_format | dspace |
| spelling | utm.eprints-765452018-04-30T13:30:42Z http://eprints.utm.my/76545/ Optimization of cordycepin extraction from cordyceps militaris fermentation broth Soltani, M. Abd Malek, R. Ware, I. Ramli, S. Elsayed, E. A. Aziz, R. El-Enshasy, H. A. TP Chemical technology Cordyceps is one of the components of traditional Chinese medicine. This mushroom becomes worldwide famous due to its significant therapeutic effects on various diseases. Nucleoside like cordycepin, a major bioactive compound from Cordyceps militaris, is commonly known as promising anticancer and antitumor compound. The aim of study is to determine an optimal mixture ratio of solvent-solvent-based extraction method, which is used for extraction of cordycepin, from cultivated Cordyceps militaris DSMZ 23612 fermentation broth. Hence, the optimization process was performed using statistical (RSM) design leaded an optimal cordycepin extraction using solvent mixture including hot water (23%), ethanol (30%), methanol (25%) and ethyl acetate (22%). In addition, the final extracted cordycepin (786.94 mgL-1 of 81% purity) was achieved through extraction parameters as sample: solvent ratio (v/v), extraction temperature, extraction time and frequency at (1:10), 35 °C, 90 min and 1 cycle, respectively. The experimental values obtained were fit with those predicted, thus indicate the suitability of RSM and method for optimization of cordycepin extraction. Scientific Publishers 2017 Article PeerReviewed Soltani, M. and Abd Malek, R. and Ware, I. and Ramli, S. and Elsayed, E. A. and Aziz, R. and El-Enshasy, H. A. (2017) Optimization of cordycepin extraction from cordyceps militaris fermentation broth. Journal of Scientific and Industrial Research, 76 (6). pp. 355-361. ISSN 0022-4456 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029863241&partnerID=40&md5=2d30058e1ce20b0bca6cad42b465ae63 http://nopr.niscair.res.in/handle/123456789/42051 |
| spellingShingle | TP Chemical technology Soltani, M. Abd Malek, R. Ware, I. Ramli, S. Elsayed, E. A. Aziz, R. El-Enshasy, H. A. Optimization of cordycepin extraction from cordyceps militaris fermentation broth |
| title | Optimization of cordycepin extraction from cordyceps militaris fermentation broth |
| title_full | Optimization of cordycepin extraction from cordyceps militaris fermentation broth |
| title_fullStr | Optimization of cordycepin extraction from cordyceps militaris fermentation broth |
| title_full_unstemmed | Optimization of cordycepin extraction from cordyceps militaris fermentation broth |
| title_short | Optimization of cordycepin extraction from cordyceps militaris fermentation broth |
| title_sort | optimization of cordycepin extraction from cordyceps militaris fermentation broth |
| topic | TP Chemical technology |
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