Strontium doped injectable bone cement for potential drug delivery applications
Microwave assisted wet precipitation method was used to synthesize calcium deficient strontium doped β-tricalcium phosphate (Sr-βTCP) with a chemical formula of Ca2.96-xSrx(PO4)2. Sr-βTCP was reacted with monocalcium phosphate monohydrate [Ca(H2PO4)2.H2O, MCPM] in presence of water to furnish corres...
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| Format: | Article |
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Elsevier Ltd
2017
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| _version_ | 1796862599798718464 |
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| author | Taha, A. Akram, M. Jawad, Z. Alshemary, A. Z. Hussain, R. |
| author_facet | Taha, A. Akram, M. Jawad, Z. Alshemary, A. Z. Hussain, R. |
| author_sort | Taha, A. |
| collection | ePrints |
| description | Microwave assisted wet precipitation method was used to synthesize calcium deficient strontium doped β-tricalcium phosphate (Sr-βTCP) with a chemical formula of Ca2.96-xSrx(PO4)2. Sr-βTCP was reacted with monocalcium phosphate monohydrate [Ca(H2PO4)2.H2O, MCPM] in presence of water to furnish corresponding Sr containing brushite cement (Sr-Brc). The samples were characterized by using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). Strontium content in the prepared samples was determined by using inductively coupled plasma optical emission spectrometry (ICP-OES). The effect of Sr2+ ions on the structural, mechanical, setting properties and drug release of the cement is reported. Incorporation of Sr2+ ions improved the injectability, setting time and mechanical properties of the Brc. The release profiles of antibiotics incorporated in Brc and Sr-Brc confirmed that the Sr incorporation into the Brc results in the efficient release of the antibiotics from the cement. |
| first_indexed | 2024-03-05T20:14:04Z |
| format | Article |
| id | utm.eprints-76932 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:14:04Z |
| publishDate | 2017 |
| publisher | Elsevier Ltd |
| record_format | dspace |
| spelling | utm.eprints-769322018-04-30T14:26:54Z http://eprints.utm.my/76932/ Strontium doped injectable bone cement for potential drug delivery applications Taha, A. Akram, M. Jawad, Z. Alshemary, A. Z. Hussain, R. QD Chemistry Microwave assisted wet precipitation method was used to synthesize calcium deficient strontium doped β-tricalcium phosphate (Sr-βTCP) with a chemical formula of Ca2.96-xSrx(PO4)2. Sr-βTCP was reacted with monocalcium phosphate monohydrate [Ca(H2PO4)2.H2O, MCPM] in presence of water to furnish corresponding Sr containing brushite cement (Sr-Brc). The samples were characterized by using X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM). Strontium content in the prepared samples was determined by using inductively coupled plasma optical emission spectrometry (ICP-OES). The effect of Sr2+ ions on the structural, mechanical, setting properties and drug release of the cement is reported. Incorporation of Sr2+ ions improved the injectability, setting time and mechanical properties of the Brc. The release profiles of antibiotics incorporated in Brc and Sr-Brc confirmed that the Sr incorporation into the Brc results in the efficient release of the antibiotics from the cement. Elsevier Ltd 2017 Article PeerReviewed Taha, A. and Akram, M. and Jawad, Z. and Alshemary, A. Z. and Hussain, R. (2017) Strontium doped injectable bone cement for potential drug delivery applications. Materials Science and Engineering C, 80 . pp. 93-101. ISSN 0928-4931 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019904356&doi=10.1016%2fj.msec.2017.05.117&partnerID=40&md5=43427469734e463c47f0bf3d59b4ede4 DOI:10.1016/j.msec.2017.05.117 |
| spellingShingle | QD Chemistry Taha, A. Akram, M. Jawad, Z. Alshemary, A. Z. Hussain, R. Strontium doped injectable bone cement for potential drug delivery applications |
| title | Strontium doped injectable bone cement for potential drug delivery applications |
| title_full | Strontium doped injectable bone cement for potential drug delivery applications |
| title_fullStr | Strontium doped injectable bone cement for potential drug delivery applications |
| title_full_unstemmed | Strontium doped injectable bone cement for potential drug delivery applications |
| title_short | Strontium doped injectable bone cement for potential drug delivery applications |
| title_sort | strontium doped injectable bone cement for potential drug delivery applications |
| topic | QD Chemistry |
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