Towards gene network estimation with structure learning
Gene network is a representation of gene interactions. A gene usually collaborates with other genes in order to function. Understanding these interactions is a crucial step towards understanding how our body functions. Bayesian Network is a technique that was initially used in Expert System to rep...
| Main Authors: | , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2006
|
| Subjects: | |
| Online Access: | http://eprints.utm.my/8019/1/SafaaiDeris2006_TowardsGeneNetworkEstimationWith.pdf |
| _version_ | 1825910138157924352 |
|---|---|
| author | Zainudin, Suhaila Deris, Safaai |
| author_facet | Zainudin, Suhaila Deris, Safaai |
| author_sort | Zainudin, Suhaila |
| collection | ePrints |
| description | Gene network is a representation of gene interactions. A gene usually collaborates with other genes in order
to function. Understanding these interactions is a crucial step towards understanding how our body
functions. Bayesian Network is a technique that was initially used in Expert System to represent expert
knowledge. Since the pioneer work of Friedman et al. that applied this technique to analyse gene
expression data, other researchers have enhanced the technique further. This research concentrates on
enhancing Bayesian Network technique fro learning gene network. In order to get better results, Bayesian
technique will be used with prior knowledge. The tool that is used to learn the gene network is
PNL(Probabilistic Network Library). Early results show that PNL can be used to recover gene network for
3 subnetworks for S.Cerevisiae. These 3 subnetworks has been learned using PNL with varying success.
The next step in this research is to learn the gene network from the dataset of 800 genes. The knowledge
that will be gained will be used to produce a better approach to learning gene network using Bayesian
network technique |
| first_indexed | 2024-03-05T18:12:33Z |
| format | Conference or Workshop Item |
| id | utm.eprints-8019 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T18:12:33Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | utm.eprints-80192010-10-12T07:07:03Z http://eprints.utm.my/8019/ Towards gene network estimation with structure learning Zainudin, Suhaila Deris, Safaai QA75 Electronic computers. Computer science Gene network is a representation of gene interactions. A gene usually collaborates with other genes in order to function. Understanding these interactions is a crucial step towards understanding how our body functions. Bayesian Network is a technique that was initially used in Expert System to represent expert knowledge. Since the pioneer work of Friedman et al. that applied this technique to analyse gene expression data, other researchers have enhanced the technique further. This research concentrates on enhancing Bayesian Network technique fro learning gene network. In order to get better results, Bayesian technique will be used with prior knowledge. The tool that is used to learn the gene network is PNL(Probabilistic Network Library). Early results show that PNL can be used to recover gene network for 3 subnetworks for S.Cerevisiae. These 3 subnetworks has been learned using PNL with varying success. The next step in this research is to learn the gene network from the dataset of 800 genes. The knowledge that will be gained will be used to produce a better approach to learning gene network using Bayesian network technique 2006 Conference or Workshop Item NonPeerReviewed application/pdf en http://eprints.utm.my/8019/1/SafaaiDeris2006_TowardsGeneNetworkEstimationWith.pdf Zainudin, Suhaila and Deris, Safaai (2006) Towards gene network estimation with structure learning. In: Proceedings of the Postgraduate Annual Research Seminar 2006 (PARS 2006), 24 - 25 May 2006, Postgraduate Studies Department FSKSM, UTM Skudai. |
| spellingShingle | QA75 Electronic computers. Computer science Zainudin, Suhaila Deris, Safaai Towards gene network estimation with structure learning |
| title | Towards gene network estimation with structure learning
|
| title_full | Towards gene network estimation with structure learning
|
| title_fullStr | Towards gene network estimation with structure learning
|
| title_full_unstemmed | Towards gene network estimation with structure learning
|
| title_short | Towards gene network estimation with structure learning
|
| title_sort | towards gene network estimation with structure learning |
| topic | QA75 Electronic computers. Computer science |
| url | http://eprints.utm.my/8019/1/SafaaiDeris2006_TowardsGeneNetworkEstimationWith.pdf |
| work_keys_str_mv | AT zainudinsuhaila towardsgenenetworkestimationwithstructurelearning AT derissafaai towardsgenenetworkestimationwithstructurelearning |