Recent advances in drug delivery of polymeric nano-micelles
In clinical studies, drugs with hydrophobic characteristic usually reflect low bioavailability, poor drug absorption, and inability to achieve the therapeutic concentration in blood. The production of poor solubility drugs, in abundance, by pharmaceutical industries calls for an urgent need to find...
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| Format: | Article |
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Bentham Science Publ. Ltd.
2017
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| _version_ | 1796863204785127424 |
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| author | Aziz, Z. A. A. Ahmad, A. Mohd. Setapar, S. H. Hassan, H. Lokhat, D. Kamal, M. A. Ashraf, G. M. |
| author_facet | Aziz, Z. A. A. Ahmad, A. Mohd. Setapar, S. H. Hassan, H. Lokhat, D. Kamal, M. A. Ashraf, G. M. |
| author_sort | Aziz, Z. A. A. |
| collection | ePrints |
| description | In clinical studies, drugs with hydrophobic characteristic usually reflect low bioavailability, poor drug absorption, and inability to achieve the therapeutic concentration in blood. The production of poor solubility drugs, in abundance, by pharmaceutical industries calls for an urgent need to find the alternatives for resolving the above mentioned shortcomings. Poor water solubility drugs loaded with polymeric micelle seem to be the best alternative to enhance drugs solubility and bioavailability. Polymeric micelle, formed by self-assembled of amphiphilic block copolymers in aqueous environment, functioned as solubilizing agent for hydrophobic drug. This review discusses the fundamentals of polymeric micelle as drug carrier through representative literature, and demonstrates some applications in various clinical trials. The structure, characteristic, and formation of polymeric micelle have been discussed firstly. Next, this manuscript focuses on the potential of polymeric micelles as drug vehicle in oral, transdermal routes, and anti-cancer agent. Several results from previous studies have been reproduced in this review in order to prove the efficacy of the micelles in delivering hydrophobic drugs. Lastly, future strategies to broaden the application of polymeric micelles in pharmaceutical industries have been highlighted. |
| first_indexed | 2024-03-05T20:23:15Z |
| format | Article |
| id | utm.eprints-80518 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:23:15Z |
| publishDate | 2017 |
| publisher | Bentham Science Publ. Ltd. |
| record_format | dspace |
| spelling | utm.eprints-805182019-05-22T06:50:09Z http://eprints.utm.my/80518/ Recent advances in drug delivery of polymeric nano-micelles Aziz, Z. A. A. Ahmad, A. Mohd. Setapar, S. H. Hassan, H. Lokhat, D. Kamal, M. A. Ashraf, G. M. Q Science (General) In clinical studies, drugs with hydrophobic characteristic usually reflect low bioavailability, poor drug absorption, and inability to achieve the therapeutic concentration in blood. The production of poor solubility drugs, in abundance, by pharmaceutical industries calls for an urgent need to find the alternatives for resolving the above mentioned shortcomings. Poor water solubility drugs loaded with polymeric micelle seem to be the best alternative to enhance drugs solubility and bioavailability. Polymeric micelle, formed by self-assembled of amphiphilic block copolymers in aqueous environment, functioned as solubilizing agent for hydrophobic drug. This review discusses the fundamentals of polymeric micelle as drug carrier through representative literature, and demonstrates some applications in various clinical trials. The structure, characteristic, and formation of polymeric micelle have been discussed firstly. Next, this manuscript focuses on the potential of polymeric micelles as drug vehicle in oral, transdermal routes, and anti-cancer agent. Several results from previous studies have been reproduced in this review in order to prove the efficacy of the micelles in delivering hydrophobic drugs. Lastly, future strategies to broaden the application of polymeric micelles in pharmaceutical industries have been highlighted. Bentham Science Publ. Ltd. 2017 Article PeerReviewed Aziz, Z. A. A. and Ahmad, A. and Mohd. Setapar, S. H. and Hassan, H. and Lokhat, D. and Kamal, M. A. and Ashraf, G. M. (2017) Recent advances in drug delivery of polymeric nano-micelles. Current Drug Metabolism, 18 (1). pp. 16-29. ISSN 1389-2002 http://dx.doi.org/10.2174/1389200217666160921143616 DOI:10.2174/1389200217666160921143616 |
| spellingShingle | Q Science (General) Aziz, Z. A. A. Ahmad, A. Mohd. Setapar, S. H. Hassan, H. Lokhat, D. Kamal, M. A. Ashraf, G. M. Recent advances in drug delivery of polymeric nano-micelles |
| title | Recent advances in drug delivery of polymeric nano-micelles |
| title_full | Recent advances in drug delivery of polymeric nano-micelles |
| title_fullStr | Recent advances in drug delivery of polymeric nano-micelles |
| title_full_unstemmed | Recent advances in drug delivery of polymeric nano-micelles |
| title_short | Recent advances in drug delivery of polymeric nano-micelles |
| title_sort | recent advances in drug delivery of polymeric nano micelles |
| topic | Q Science (General) |
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