Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
Escherichia coli (E. coli) has been established to be a native producer of succinic acid (a platform chemical with different applications) via mixed acid fermentation reactions. Genome-scale metabolic models (GEMs) of E. coli have been published with capabilities of predicting strain design strategi...
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| Format: | Article |
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2017
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| author | Sajo Mienda, Bashir Mohd. Salleh, Faezah |
| author_facet | Sajo Mienda, Bashir Mohd. Salleh, Faezah |
| author_sort | Sajo Mienda, Bashir |
| collection | ePrints |
| description | Escherichia coli (E. coli) has been established to be a native producer of succinic acid (a platform chemical with different applications) via mixed acid fermentation reactions. Genome-scale metabolic models (GEMs) of E. coli have been published with capabilities of predicting strain design strategies for the production of bio-based succinic acid. Proof-of-principle strains are fundamentally constructed as a starting point for systems strategies for industrial strains development. Here, we review for the first time, the use of E. coli GEMs for construction of proof-of-principles strains for increasing succinic acid production. Specific case studies, where E. coli proof-of-principle strains were constructed for increasing bio-based succinic acid production from glucose and glycerol carbon sources have been highlighted. In addition, a propose systems strategies for industrial strain development that could be applicable for future microbial succinic acid production guided by GEMs have been presented. |
| first_indexed | 2024-03-05T20:25:45Z |
| format | Article |
| id | utm.eprints-81356 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:25:45Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | utm.eprints-813562019-08-04T03:34:10Z http://eprints.utm.my/81356/ Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives Sajo Mienda, Bashir Mohd. Salleh, Faezah Q Science (General) Escherichia coli (E. coli) has been established to be a native producer of succinic acid (a platform chemical with different applications) via mixed acid fermentation reactions. Genome-scale metabolic models (GEMs) of E. coli have been published with capabilities of predicting strain design strategies for the production of bio-based succinic acid. Proof-of-principle strains are fundamentally constructed as a starting point for systems strategies for industrial strains development. Here, we review for the first time, the use of E. coli GEMs for construction of proof-of-principles strains for increasing succinic acid production. Specific case studies, where E. coli proof-of-principle strains were constructed for increasing bio-based succinic acid production from glucose and glycerol carbon sources have been highlighted. In addition, a propose systems strategies for industrial strain development that could be applicable for future microbial succinic acid production guided by GEMs have been presented. 2017 Article PeerReviewed Sajo Mienda, Bashir and Mohd. Salleh, Faezah (2017) Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives. AIMS Bioengineering, 4 (4). pp. 418-430. ISSN 2375-1495 http://dx.doi.org/10.3934/bioeng.2017.4.418. DOI:10.3934/bioeng.2017.4.418. |
| spellingShingle | Q Science (General) Sajo Mienda, Bashir Mohd. Salleh, Faezah Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives |
| title | Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives |
| title_full | Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives |
| title_fullStr | Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives |
| title_full_unstemmed | Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives |
| title_short | Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives |
| title_sort | bio succinic acid production escherichia coli strains design from genome scale perspectives |
| topic | Q Science (General) |
| work_keys_str_mv | AT sajomiendabashir biosuccinicacidproductionescherichiacolistrainsdesignfromgenomescaleperspectives AT mohdsallehfaezah biosuccinicacidproductionescherichiacolistrainsdesignfromgenomescaleperspectives |