Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y
The antibacterial activities, cytotoxicity, and wound healing of amine(3-aminopropyltriethoxysilane (APTES))-functionalised zeolite Y against normal human fibroblast cells were studied. The characterisation of unmodified and amine-functionalised zeolites Y (Z, ZA 0.04, ZA 0.4, and ZA 0.6) by Fourier...
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| Format: | Conference or Workshop Item |
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2018
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| _version_ | 1796863574229909504 |
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| author | Nik Malek, Nik Ahmad Nizam Jemon, Khairunadwa Hassan, Muhammad Hariz Asraf Sani, Nor Suriani Ishak, Siti Nabihan Awaluddin, Muhammad Zulhilmi Amir |
| author_facet | Nik Malek, Nik Ahmad Nizam Jemon, Khairunadwa Hassan, Muhammad Hariz Asraf Sani, Nor Suriani Ishak, Siti Nabihan Awaluddin, Muhammad Zulhilmi Amir |
| author_sort | Nik Malek, Nik Ahmad Nizam |
| collection | ePrints |
| description | The antibacterial activities, cytotoxicity, and wound healing of amine(3-aminopropyltriethoxysilane (APTES))-functionalised zeolite Y against normal human fibroblast cells were studied. The characterisation of unmodified and amine-functionalised zeolites Y (Z, ZA 0.04, ZA 0.4, and ZA 0.6) by Fourier transform infrared spectroscopy, X-ray powder diffraction, and energy dispersive X-ray analysis proved that the APTES molecules were grafted onto the zeolite Y surface without distorting its framework structure. All amine-functionalised zeolite Y samples possessed antibacterial activities against several ATCC bacteria that were correlated with the increased amount of APTES on the zeolite Y surface. Conversely, when a higher concentration of APTES was grafted on the zeolite Y, higher cytotoxicity was observed against the fibroblast cells. Although the ZA 0.6 sample (zeolite Y functionalised with 0.6 M of APTES) had higher antibacterial activity, it was cytotoxic to the cells. Therefore, the selection of an antibacterial agent for human treatment purposes must also consider its cytotoxicity effect against human cells to ensure it is biocompatible. |
| first_indexed | 2024-03-05T20:28:47Z |
| format | Conference or Workshop Item |
| id | utm.eprints-82383 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:28:47Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | utm.eprints-823832019-10-02T03:30:53Z http://eprints.utm.my/82383/ Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y Nik Malek, Nik Ahmad Nizam Jemon, Khairunadwa Hassan, Muhammad Hariz Asraf Sani, Nor Suriani Ishak, Siti Nabihan Awaluddin, Muhammad Zulhilmi Amir The antibacterial activities, cytotoxicity, and wound healing of amine(3-aminopropyltriethoxysilane (APTES))-functionalised zeolite Y against normal human fibroblast cells were studied. The characterisation of unmodified and amine-functionalised zeolites Y (Z, ZA 0.04, ZA 0.4, and ZA 0.6) by Fourier transform infrared spectroscopy, X-ray powder diffraction, and energy dispersive X-ray analysis proved that the APTES molecules were grafted onto the zeolite Y surface without distorting its framework structure. All amine-functionalised zeolite Y samples possessed antibacterial activities against several ATCC bacteria that were correlated with the increased amount of APTES on the zeolite Y surface. Conversely, when a higher concentration of APTES was grafted on the zeolite Y, higher cytotoxicity was observed against the fibroblast cells. Although the ZA 0.6 sample (zeolite Y functionalised with 0.6 M of APTES) had higher antibacterial activity, it was cytotoxic to the cells. Therefore, the selection of an antibacterial agent for human treatment purposes must also consider its cytotoxicity effect against human cells to ensure it is biocompatible. 2018 Conference or Workshop Item PeerReviewed Nik Malek, Nik Ahmad Nizam and Jemon, Khairunadwa and Hassan, Muhammad Hariz Asraf and Sani, Nor Suriani and Ishak, Siti Nabihan and Awaluddin, Muhammad Zulhilmi Amir (2018) Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y. In: UTM-Emerging Scientist Conference (UTM-ESCON) 2018. |
| spellingShingle | Nik Malek, Nik Ahmad Nizam Jemon, Khairunadwa Hassan, Muhammad Hariz Asraf Sani, Nor Suriani Ishak, Siti Nabihan Awaluddin, Muhammad Zulhilmi Amir Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y |
| title | Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y |
| title_full | Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y |
| title_fullStr | Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y |
| title_full_unstemmed | Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y |
| title_short | Antibacterial, cytotoxicity, and wound healing studies of amine-functionalized zeolite y |
| title_sort | antibacterial cytotoxicity and wound healing studies of amine functionalized zeolite y |
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