Reverse micelle extraction of antibiotics
Many biomolecules such as proteins, enzymes and metal ions could be solubilised effectively into the reverse micelle organic solvents. Therefore, this opens the possibility of using the existing liquid-liquid extraction technology and utilizing reverse micelles for large-scale extraction in downstre...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit UTM Press
2008
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| Subjects: | |
| Online Access: | http://eprints.utm.my/8511/1/UTMjurnalTEK_49F_DIS%5B06%5D.pdf |
| _version_ | 1796854394866630656 |
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| author | Mohd. Setapar, Siti Hamidah Shiew, Wei Lau Toorisaka, Eiichi Goto, Masahiro Furusaki, Shintaro Mat, Hanapi |
| author_facet | Mohd. Setapar, Siti Hamidah Shiew, Wei Lau Toorisaka, Eiichi Goto, Masahiro Furusaki, Shintaro Mat, Hanapi |
| author_sort | Mohd. Setapar, Siti Hamidah |
| collection | ePrints |
| description | Many biomolecules such as proteins, enzymes and metal ions could be solubilised effectively into the reverse micelle organic solvents. Therefore, this opens the possibility of using the existing liquid-liquid extraction technology and utilizing reverse micelles for large-scale extraction in downstream processing. So far, there has been very limited research on the use of reverse micelle for antibiotics extraction. Thus, an attempt was made to use dioleylphosphoric acid (DOLPA) reverse micelle to extract antibiotics. It was found that pH, surfactant concentration, as well as antibiotic types and concentration have a significant effect on the solubilizing capacity of antibiotics in the DOLPA reverse micelles system. At optimum conditions, about 63 % of penicillin G could be extracted during forward extraction, and 54 % in backward extraction. |
| first_indexed | 2024-03-05T18:13:39Z |
| format | Article |
| id | utm.eprints-8511 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T18:13:39Z |
| publishDate | 2008 |
| publisher | Penerbit UTM Press |
| record_format | dspace |
| spelling | utm.eprints-85112010-10-25T04:10:45Z http://eprints.utm.my/8511/ Reverse micelle extraction of antibiotics Mohd. Setapar, Siti Hamidah Shiew, Wei Lau Toorisaka, Eiichi Goto, Masahiro Furusaki, Shintaro Mat, Hanapi TP Chemical technology Many biomolecules such as proteins, enzymes and metal ions could be solubilised effectively into the reverse micelle organic solvents. Therefore, this opens the possibility of using the existing liquid-liquid extraction technology and utilizing reverse micelles for large-scale extraction in downstream processing. So far, there has been very limited research on the use of reverse micelle for antibiotics extraction. Thus, an attempt was made to use dioleylphosphoric acid (DOLPA) reverse micelle to extract antibiotics. It was found that pH, surfactant concentration, as well as antibiotic types and concentration have a significant effect on the solubilizing capacity of antibiotics in the DOLPA reverse micelles system. At optimum conditions, about 63 % of penicillin G could be extracted during forward extraction, and 54 % in backward extraction. Penerbit UTM Press 2008-12 Article PeerReviewed application/pdf en http://eprints.utm.my/8511/1/UTMjurnalTEK_49F_DIS%5B06%5D.pdf Mohd. Setapar, Siti Hamidah and Shiew, Wei Lau and Toorisaka, Eiichi and Goto, Masahiro and Furusaki, Shintaro and Mat, Hanapi (2008) Reverse micelle extraction of antibiotics. Jurnal Teknologi F (49F). pp. 69-79. ISSN 0127-9696 |
| spellingShingle | TP Chemical technology Mohd. Setapar, Siti Hamidah Shiew, Wei Lau Toorisaka, Eiichi Goto, Masahiro Furusaki, Shintaro Mat, Hanapi Reverse micelle extraction of antibiotics |
| title | Reverse micelle extraction of antibiotics |
| title_full | Reverse micelle extraction of antibiotics |
| title_fullStr | Reverse micelle extraction of antibiotics |
| title_full_unstemmed | Reverse micelle extraction of antibiotics |
| title_short | Reverse micelle extraction of antibiotics |
| title_sort | reverse micelle extraction of antibiotics |
| topic | TP Chemical technology |
| url | http://eprints.utm.my/8511/1/UTMjurnalTEK_49F_DIS%5B06%5D.pdf |
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