Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring
Background: In the current study, a series of novel thiophene chalcones (3a-g) and pyrazole containing thiophene derivatives (6a-g) were designed as potential anti-fungal agents and evaluated in silico for drug-likeness behavior. Methods: The titled compounds were synthesized using Claisen–Schmidt r...
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Bentham Science Publishers B.V.
2018
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| _version_ | 1796864089594527744 |
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| author | Al-Maqtari, Helmi M. Jamalis, Joazaizulfazli Chander, Subhash M. Sirat, Hasnah Naveen, Shivalingegowda Lokanath, Neratur K. M. Bohari, Siti P. Bhagwat, Deepak P. Sankaranarayanan, Murugesan |
| author_facet | Al-Maqtari, Helmi M. Jamalis, Joazaizulfazli Chander, Subhash M. Sirat, Hasnah Naveen, Shivalingegowda Lokanath, Neratur K. M. Bohari, Siti P. Bhagwat, Deepak P. Sankaranarayanan, Murugesan |
| author_sort | Al-Maqtari, Helmi M. |
| collection | ePrints |
| description | Background: In the current study, a series of novel thiophene chalcones (3a-g) and pyrazole containing thiophene derivatives (6a-g) were designed as potential anti-fungal agents and evaluated in silico for drug-likeness behavior. Methods: The titled compounds were synthesized using Claisen–Schmidt reaction of 3-methyl-2-thiophenecarboxaldehyde (1) with several acetophenone derivatives (2a-g) followed by cyclization reactions using hydrazine hydrate to form new compounds (6a-g) in good to excellent yield. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and Mass spectral analysis. All the synthesized chalcones (3a-g) and pyrazole derivatives (6a-g) were screened for antifungal potency using Candida albicans (MTCC 3958) and Aspergillus niger (MTCC 9933) using fluconazole as standard drug. Results & Conclusion: The assay results revealed interesting finding that, compound 6c showed significant activity against both the tested fungal strains. |
| first_indexed | 2024-03-05T20:36:36Z |
| format | Article |
| id | utm.eprints-85669 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:36:36Z |
| publishDate | 2018 |
| publisher | Bentham Science Publishers B.V. |
| record_format | dspace |
| spelling | utm.eprints-856692020-07-20T01:24:12Z http://eprints.utm.my/85669/ Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring Al-Maqtari, Helmi M. Jamalis, Joazaizulfazli Chander, Subhash M. Sirat, Hasnah Naveen, Shivalingegowda Lokanath, Neratur K. M. Bohari, Siti P. Bhagwat, Deepak P. Sankaranarayanan, Murugesan QD Chemistry Background: In the current study, a series of novel thiophene chalcones (3a-g) and pyrazole containing thiophene derivatives (6a-g) were designed as potential anti-fungal agents and evaluated in silico for drug-likeness behavior. Methods: The titled compounds were synthesized using Claisen–Schmidt reaction of 3-methyl-2-thiophenecarboxaldehyde (1) with several acetophenone derivatives (2a-g) followed by cyclization reactions using hydrazine hydrate to form new compounds (6a-g) in good to excellent yield. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and Mass spectral analysis. All the synthesized chalcones (3a-g) and pyrazole derivatives (6a-g) were screened for antifungal potency using Candida albicans (MTCC 3958) and Aspergillus niger (MTCC 9933) using fluconazole as standard drug. Results & Conclusion: The assay results revealed interesting finding that, compound 6c showed significant activity against both the tested fungal strains. Bentham Science Publishers B.V. 2018 Article PeerReviewed Al-Maqtari, Helmi M. and Jamalis, Joazaizulfazli and Chander, Subhash and M. Sirat, Hasnah and Naveen, Shivalingegowda and Lokanath, Neratur K. and M. Bohari, Siti P. and Bhagwat, Deepak P. and Sankaranarayanan, Murugesan (2018) Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring. Letters in Drug Design and Discovery, 15 (11). pp. 1202-1210. ISSN 1570-1808 http://dx.doi.org/10.2174/1570180815666180328144325 DOI:10.2174/1570180815666180328144325 |
| spellingShingle | QD Chemistry Al-Maqtari, Helmi M. Jamalis, Joazaizulfazli Chander, Subhash M. Sirat, Hasnah Naveen, Shivalingegowda Lokanath, Neratur K. M. Bohari, Siti P. Bhagwat, Deepak P. Sankaranarayanan, Murugesan Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring |
| title | Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring |
| title_full | Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring |
| title_fullStr | Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring |
| title_full_unstemmed | Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring |
| title_short | Synthesis, in silico and antifungal studies of novel thiophene analogues containing pyrazole ring |
| title_sort | synthesis in silico and antifungal studies of novel thiophene analogues containing pyrazole ring |
| topic | QD Chemistry |
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