| Summary: | A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fungal activity against Candida albicans and Aspergillus niger using fluconazole as reference drug. The assay revealed that, compound 3k showed significant activity (14 mm ZOI, 64 µg/mL IC50 and 15 mm ZOI, >32 µg/mL IC50) against C. albicans and A. niger, respectively.
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