Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity
Nanostructured lipid carrier (NLC) was studied as a system to transport Ficus deltoidea extracts through the skin. The thin film ultra-sonication dispersion (TFUD) technique and double-emulsion solvent diffusion (DESD) techniques were performed to compare encapsulation efficiency (EE) of the two met...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Springer
2021
|
| Subjects: |
| _version_ | 1796865139585056768 |
|---|---|
| author | Abdul Ghani, Siti Maria Roslan, Nur Zatul Iradah Muda, Rohaiza Abdul Aziz, Azila |
| author_facet | Abdul Ghani, Siti Maria Roslan, Nur Zatul Iradah Muda, Rohaiza Abdul Aziz, Azila |
| author_sort | Abdul Ghani, Siti Maria |
| collection | ePrints |
| description | Nanostructured lipid carrier (NLC) was studied as a system to transport Ficus deltoidea extracts through the skin. The thin film ultra-sonication dispersion (TFUD) technique and double-emulsion solvent diffusion (DESD) techniques were performed to compare encapsulation efficiency (EE) of the two methods. The DESD displayed superior performance for encapsulation of F. deltoidea extracts which was 67.92 ± 10.55%. Next, different types of lipids were assessed to determine their effects on the characteristics of F. deltoidea–loaded NLC prepared via the DESD method. Fatty acids were superior to triglycerides for the formulation of NLC. The final NLC formulation selected was stearic acid (SA) as solid lipid and oleic acid (OA) as liquid lipid, at a total ratio of 1:1, and poly(vinyl alcohol) (PVA) as a stabiliser. The delivery system exerted exceptional transdermal transport properties. F. deltoidea–loaded NLC successfully and more effectively reduced melanin, when compared with non-entrapped F. deltoidea extract. |
| first_indexed | 2024-03-05T20:52:25Z |
| format | Article |
| id | utm.eprints-90992 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:52:25Z |
| publishDate | 2021 |
| publisher | Springer |
| record_format | dspace |
| spelling | utm.eprints-909922021-05-31T13:29:03Z http://eprints.utm.my/90992/ Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity Abdul Ghani, Siti Maria Roslan, Nur Zatul Iradah Muda, Rohaiza Abdul Aziz, Azila TP Chemical technology Nanostructured lipid carrier (NLC) was studied as a system to transport Ficus deltoidea extracts through the skin. The thin film ultra-sonication dispersion (TFUD) technique and double-emulsion solvent diffusion (DESD) techniques were performed to compare encapsulation efficiency (EE) of the two methods. The DESD displayed superior performance for encapsulation of F. deltoidea extracts which was 67.92 ± 10.55%. Next, different types of lipids were assessed to determine their effects on the characteristics of F. deltoidea–loaded NLC prepared via the DESD method. Fatty acids were superior to triglycerides for the formulation of NLC. The final NLC formulation selected was stearic acid (SA) as solid lipid and oleic acid (OA) as liquid lipid, at a total ratio of 1:1, and poly(vinyl alcohol) (PVA) as a stabiliser. The delivery system exerted exceptional transdermal transport properties. F. deltoidea–loaded NLC successfully and more effectively reduced melanin, when compared with non-entrapped F. deltoidea extract. Springer 2021-03 Article PeerReviewed Abdul Ghani, Siti Maria and Roslan, Nur Zatul Iradah and Muda, Rohaiza and Abdul Aziz, Azila (2021) Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity. BioNanoScience, 11 (1). pp. 8-20. ISSN 2191-1630 http://dx.doi.org/10.1007/s12668-020-00786-2 |
| spellingShingle | TP Chemical technology Abdul Ghani, Siti Maria Roslan, Nur Zatul Iradah Muda, Rohaiza Abdul Aziz, Azila Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity |
| title | Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity |
| title_full | Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity |
| title_fullStr | Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity |
| title_full_unstemmed | Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity |
| title_short | Encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity |
| title_sort | encapsulation of ficus deltoidea extract in nanostructured lipid carrier for anti melanogenic activity |
| topic | TP Chemical technology |
| work_keys_str_mv | AT abdulghanisitimaria encapsulationofficusdeltoideaextractinnanostructuredlipidcarrierforantimelanogenicactivity AT roslannurzatuliradah encapsulationofficusdeltoideaextractinnanostructuredlipidcarrierforantimelanogenicactivity AT mudarohaiza encapsulationofficusdeltoideaextractinnanostructuredlipidcarrierforantimelanogenicactivity AT abdulazizazila encapsulationofficusdeltoideaextractinnanostructuredlipidcarrierforantimelanogenicactivity |