Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties
Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active couma...
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| Format: | Article |
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Bentham Science
2020
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| _version_ | 1796865265314562048 |
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| author | Abdul Razak, Nurhayatun S. Jamalis, Joazaizulfazli Chander, Subhash Abdul Wahab, Roswanira Bhagwat, Deepak P. Smith, Terry K. Sankaranarayanan, Murugesan |
| author_facet | Abdul Razak, Nurhayatun S. Jamalis, Joazaizulfazli Chander, Subhash Abdul Wahab, Roswanira Bhagwat, Deepak P. Smith, Terry K. Sankaranarayanan, Murugesan |
| author_sort | Abdul Razak, Nurhayatun S. |
| collection | ePrints |
| description | Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper. |
| first_indexed | 2024-03-05T20:54:19Z |
| format | Article |
| id | utm.eprints-91629 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:54:19Z |
| publishDate | 2020 |
| publisher | Bentham Science |
| record_format | dspace |
| spelling | utm.eprints-916292021-07-14T08:18:50Z http://eprints.utm.my/91629/ Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties Abdul Razak, Nurhayatun S. Jamalis, Joazaizulfazli Chander, Subhash Abdul Wahab, Roswanira Bhagwat, Deepak P. Smith, Terry K. Sankaranarayanan, Murugesan QD Chemistry Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper. Bentham Science 2020 Article PeerReviewed Abdul Razak, Nurhayatun S. and Jamalis, Joazaizulfazli and Chander, Subhash and Abdul Wahab, Roswanira and Bhagwat, Deepak P. and Smith, Terry K. and Sankaranarayanan, Murugesan (2020) Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties. Mini-Reviews in Organic Chemistry, 17 (7). pp. 780-794. ISSN 1570-193X http://dx.doi.org/10.2174/1570193X16666191029111051 |
| spellingShingle | QD Chemistry Abdul Razak, Nurhayatun S. Jamalis, Joazaizulfazli Chander, Subhash Abdul Wahab, Roswanira Bhagwat, Deepak P. Smith, Terry K. Sankaranarayanan, Murugesan Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties |
| title | Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties |
| title_full | Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties |
| title_fullStr | Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties |
| title_full_unstemmed | Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties |
| title_short | Coumarin-oxadiazole derivatives: Synthesis and pharmacological properties |
| title_sort | coumarin oxadiazole derivatives synthesis and pharmacological properties |
| topic | QD Chemistry |
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