Plant bioactive peptides: Current status and prospects towards use on human health
Large numbers of bioactive peptides with potential applications in protecting against human diseases have been identified from plant sources. In this review, we summarized recent progress in the research of plant-derived bioactive peptides, encompassing their production, biological effects, and mech...
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| Format: | Article |
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Bentham Science Publ Ltd
2020
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| _version_ | 1796865284006477824 |
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| author | Chai, Tsun Thai Ee, Kah Yaw Kumar, D. Thirumal Abd. Manan, Fazilah Wong, Fai Chu |
| author_facet | Chai, Tsun Thai Ee, Kah Yaw Kumar, D. Thirumal Abd. Manan, Fazilah Wong, Fai Chu |
| author_sort | Chai, Tsun Thai |
| collection | ePrints |
| description | Large numbers of bioactive peptides with potential applications in protecting against human diseases have been identified from plant sources. In this review, we summarized recent progress in the research of plant-derived bioactive peptides, encompassing their production, biological effects, and mechanisms. This review focuses on antioxidant, antimicrobial, antidiabetic, and anticancer peptides, giving special attention to evidence derived from cellular and animal models. Studies investigating peptides with known sequences and well- characterized peptidic fractions or protein hydrolysates will be discussed. The use of molecular docking tools to elucidate inter-molecular interactions between bioactive peptides and target proteins is highlighted. In conclusion, the accumulating evidence from in silico, in vitro and in vivo studies to date supports the envisioned applications of plant peptides as natural antioxidants as well as health-promoting agents. Notwithstanding, much work is still required before the envisioned applications of plant peptides can be realized. To this end, future researches for addressing current gaps were proposed. |
| first_indexed | 2024-03-05T20:54:39Z |
| format | Article |
| id | utm.eprints-91723 |
| institution | Universiti Teknologi Malaysia - ePrints |
| last_indexed | 2024-03-05T20:54:39Z |
| publishDate | 2020 |
| publisher | Bentham Science Publ Ltd |
| record_format | dspace |
| spelling | utm.eprints-917232021-07-27T06:23:41Z http://eprints.utm.my/91723/ Plant bioactive peptides: Current status and prospects towards use on human health Chai, Tsun Thai Ee, Kah Yaw Kumar, D. Thirumal Abd. Manan, Fazilah Wong, Fai Chu QK Botany Large numbers of bioactive peptides with potential applications in protecting against human diseases have been identified from plant sources. In this review, we summarized recent progress in the research of plant-derived bioactive peptides, encompassing their production, biological effects, and mechanisms. This review focuses on antioxidant, antimicrobial, antidiabetic, and anticancer peptides, giving special attention to evidence derived from cellular and animal models. Studies investigating peptides with known sequences and well- characterized peptidic fractions or protein hydrolysates will be discussed. The use of molecular docking tools to elucidate inter-molecular interactions between bioactive peptides and target proteins is highlighted. In conclusion, the accumulating evidence from in silico, in vitro and in vivo studies to date supports the envisioned applications of plant peptides as natural antioxidants as well as health-promoting agents. Notwithstanding, much work is still required before the envisioned applications of plant peptides can be realized. To this end, future researches for addressing current gaps were proposed. Bentham Science Publ Ltd 2020 Article PeerReviewed Chai, Tsun Thai and Ee, Kah Yaw and Kumar, D. Thirumal and Abd. Manan, Fazilah and Wong, Fai Chu (2020) Plant bioactive peptides: Current status and prospects towards use on human health. Protein and Peptide Letters, 27 (1). pp. 623-642. ISSN 1875-5305 http://dx.doi.org/10.2174/0929866527999201211195936. |
| spellingShingle | QK Botany Chai, Tsun Thai Ee, Kah Yaw Kumar, D. Thirumal Abd. Manan, Fazilah Wong, Fai Chu Plant bioactive peptides: Current status and prospects towards use on human health |
| title | Plant bioactive peptides: Current status and prospects towards use on human health |
| title_full | Plant bioactive peptides: Current status and prospects towards use on human health |
| title_fullStr | Plant bioactive peptides: Current status and prospects towards use on human health |
| title_full_unstemmed | Plant bioactive peptides: Current status and prospects towards use on human health |
| title_short | Plant bioactive peptides: Current status and prospects towards use on human health |
| title_sort | plant bioactive peptides current status and prospects towards use on human health |
| topic | QK Botany |
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