Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes
Gynura procumbens (Compositae) has been used as folk remedy for the treatment to control diabetes mellitus and hyperlipidemia. The aim of this study was to examine whether G. procumbens extract for various solvent system had an enhancing effect on glucose uptake in 3T3 adipocyte cell lines. At the c...
| Main Authors: | , , , |
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| Format: | Book Section |
| Language: | English |
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UNIMAS and Malaysian Natural Products Society
2006
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| Subjects: | |
| Online Access: | http://eprints.utm.my/921/1/Glucose_uptake_paper.pdf |
| _version_ | 1796853160856256512 |
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| author | Mohd. Bohari, Siti Pauliena Hamid, Muhajir Shaari, Khozirah Lajis, Nordin |
| author_facet | Mohd. Bohari, Siti Pauliena Hamid, Muhajir Shaari, Khozirah Lajis, Nordin |
| author_sort | Mohd. Bohari, Siti Pauliena |
| collection | ePrints |
| description | Gynura procumbens (Compositae) has been used as folk remedy for the treatment to control diabetes mellitus and hyperlipidemia. The aim of this study was to examine whether G. procumbens extract for various solvent system had an enhancing effect on glucose uptake in 3T3 adipocyte cell lines. At the concentration 0.1mg/mL of hexane fraction showed increase in glucose uptake activity 4.5 fold whereas etyl acetate fraction increased 2.2 fold at 0.005 mg/mL of compare to untreated. For butanol fraction showed dependent manner of insulin and at 0.05mg/mL of extract, glucose uptake activity was increased 1.4 fold compare to the insulin.These results suggest that the antidiabetic action of G. procumbens may be mediated throught the stimulation of glucose uptake and the potentiation of insulin action. |
| first_indexed | 2024-03-05T17:55:29Z |
| format | Book Section |
| id | utm.eprints-921 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T17:55:29Z |
| publishDate | 2006 |
| publisher | UNIMAS and Malaysian Natural Products Society |
| record_format | dspace |
| spelling | utm.eprints-9212017-09-02T08:16:32Z http://eprints.utm.my/921/ Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes Mohd. Bohari, Siti Pauliena Hamid, Muhajir Shaari, Khozirah Lajis, Nordin RM Therapeutics. Pharmacology Gynura procumbens (Compositae) has been used as folk remedy for the treatment to control diabetes mellitus and hyperlipidemia. The aim of this study was to examine whether G. procumbens extract for various solvent system had an enhancing effect on glucose uptake in 3T3 adipocyte cell lines. At the concentration 0.1mg/mL of hexane fraction showed increase in glucose uptake activity 4.5 fold whereas etyl acetate fraction increased 2.2 fold at 0.005 mg/mL of compare to untreated. For butanol fraction showed dependent manner of insulin and at 0.05mg/mL of extract, glucose uptake activity was increased 1.4 fold compare to the insulin.These results suggest that the antidiabetic action of G. procumbens may be mediated throught the stimulation of glucose uptake and the potentiation of insulin action. UNIMAS and Malaysian Natural Products Society 2006 Book Section PeerReviewed application/pdf en http://eprints.utm.my/921/1/Glucose_uptake_paper.pdf Mohd. Bohari, Siti Pauliena and Hamid, Muhajir and Shaari, Khozirah and Lajis, Nordin (2006) Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes. In: Malaysian Medicinal Plant: Chemistry and Biological Activity. UNIMAS and Malaysian Natural Products Society, Sarawak. ISBN 983-9257-7 https://www.researchgate.net/publication/268438825_GLUCOSE_UPTAKE_Stimulatory_Activity_of_Gynura_procumbens_in_3T3-F442A_adipocytes |
| spellingShingle | RM Therapeutics. Pharmacology Mohd. Bohari, Siti Pauliena Hamid, Muhajir Shaari, Khozirah Lajis, Nordin Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes |
| title | Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes |
| title_full | Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes |
| title_fullStr | Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes |
| title_full_unstemmed | Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes |
| title_short | Glucose uptake : stimulatory activity of Gynura procumbens in 3T3- F442A adipocytes |
| title_sort | glucose uptake stimulatory activity of gynura procumbens in 3t3 f442a adipocytes |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.utm.my/921/1/Glucose_uptake_paper.pdf |
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