Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation
microRNAs (miRNAs) are well known as major players in mammalian and plant genetic systems that act by regulating gene expression at the post-transcriptional level. These tiny molecules can regulate target genes (mRNAs) through either cleavage or translational inhibition. Recently, the discovery of p...
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Format: | Article |
Language: | English |
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Oxford University Press
2020
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Online Access: | http://eprints.utm.my/93669/1/AbdulFatahASamad2020_CrossKingdomRegulationbyPlantmicroRNAs.pdf |
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author | A. Samad, Abdul Fatah Kamaroddin, Mohd. Farizal Muhammad Sajad, Muhammad Sajad |
author_facet | A. Samad, Abdul Fatah Kamaroddin, Mohd. Farizal Muhammad Sajad, Muhammad Sajad |
author_sort | A. Samad, Abdul Fatah |
collection | ePrints |
description | microRNAs (miRNAs) are well known as major players in mammalian and plant genetic systems that act by regulating gene expression at the post-transcriptional level. These tiny molecules can regulate target genes (mRNAs) through either cleavage or translational inhibition. Recently, the discovery of plant-derived miRNAs showing cross-kingdom abilities to regulate mammalian gene expression has prompted exciting discussions among researchers. After being acquired orally through the diet, plant miRNAs can survive in the digestive tract, enter the circulatory system, and regulate endogenous mRNAs. Here, we review current knowledge regarding the cross-kingdom mechanisms of plant miRNAs, related controversies, and potential applications of these miRNAs in dietary therapy, which will provide new insights for plant miRNA investigations related to health issues in humans. |
first_indexed | 2024-03-05T21:00:29Z |
format | Article |
id | utm.eprints-93669 |
institution | Universiti Teknologi Malaysia - ePrints |
language | English |
last_indexed | 2024-03-05T21:00:29Z |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | dspace |
spelling | utm.eprints-936692021-12-31T08:45:16Z http://eprints.utm.my/93669/ Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation A. Samad, Abdul Fatah Kamaroddin, Mohd. Farizal Muhammad Sajad, Muhammad Sajad Q Science (General) microRNAs (miRNAs) are well known as major players in mammalian and plant genetic systems that act by regulating gene expression at the post-transcriptional level. These tiny molecules can regulate target genes (mRNAs) through either cleavage or translational inhibition. Recently, the discovery of plant-derived miRNAs showing cross-kingdom abilities to regulate mammalian gene expression has prompted exciting discussions among researchers. After being acquired orally through the diet, plant miRNAs can survive in the digestive tract, enter the circulatory system, and regulate endogenous mRNAs. Here, we review current knowledge regarding the cross-kingdom mechanisms of plant miRNAs, related controversies, and potential applications of these miRNAs in dietary therapy, which will provide new insights for plant miRNA investigations related to health issues in humans. Oxford University Press 2020 Article PeerReviewed application/pdf en http://eprints.utm.my/93669/1/AbdulFatahASamad2020_CrossKingdomRegulationbyPlantmicroRNAs.pdf A. Samad, Abdul Fatah and Kamaroddin, Mohd. Farizal and Muhammad Sajad, Muhammad Sajad (2020) Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation. Advances in Nutrition, 12 (1). pp. 197-211. ISSN 2161-8313 http://dx.doi.org/10.1093/advances/nmaa095 |
spellingShingle | Q Science (General) A. Samad, Abdul Fatah Kamaroddin, Mohd. Farizal Muhammad Sajad, Muhammad Sajad Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation |
title | Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation |
title_full | Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation |
title_fullStr | Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation |
title_full_unstemmed | Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation |
title_short | Cross-kingdom regulation by plant microRNAs provides novel insight into gene regulation |
title_sort | cross kingdom regulation by plant micrornas provides novel insight into gene regulation |
topic | Q Science (General) |
url | http://eprints.utm.my/93669/1/AbdulFatahASamad2020_CrossKingdomRegulationbyPlantmicroRNAs.pdf |
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